Erythema And Urticaria

Question 1

Menopausal (ass with sweating vs dry seen with meds), niacin (mediated by PG D2 and responds to laropiprant), CCBs, CSA, chemotherapy, vancomycin, bromocriptine, IV contrast, sildenafil, high dose IVMP

Reduced methylnictinate flushing in schizophrenia
Neuronally mediated flushing after general ana and thiopental
Alcohol in pts using topical CCI
Sulfites in wine, scombroid fish
Low amine oxidase activity - normally detoxifies dietary histamine

Answer 1

Flushing

Question 2

EM

Answer 2

Dorsal hands usually first
Keobnerize and photoaccentuated
25% with mucosal
HSV DNA may be identified in lesions

Question 3

Elevated in more that 40% of chronic urticaria cases

Answer 3

MBP

*1/3 with IgG FcR ab

Question 4

Subset of urticaria >24 hrs

Answer 4

Neutrophilic uticaria

Lesional skin shows increased TNFalpha, IL3, minor IL8

Question 5

Why should you not use cimetidine or Zantac alone to tax urticaria

Answer 5

May interfere with feedback inhibition of histamine release

Question 6

Sarna

Answer 6

Menthol, camphor, phenol

Question 7

MC physical urticaria

Answer 7

Dermatographism

*associated with famotidine, diabetes, infection, menopause, hypothyroidism

Question 8

Solar urticaria associations

Answer 8

Porphyria
LCV
Churg Strauss

Question 9

Exercise induced urticaria

Answer 9

Larger than cholinergic

Associated with autopsy