Schizophrenia Flashcards

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1
Q

What are some positive symptoms?

A

Hallucinations
Delusions
Agitation
Disorganised thinking

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2
Q

What are some negative symptoms?

A

Introversion
Apathy
Low self-esteem
Personal neglect

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3
Q

What are some cognitive symptoms?

A

Poor memory
Attention deficit
Executive dysfunction

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4
Q

What two (out of 5) things must schizophrenic patients have experienced?

A
Delusions
Hallucinations
Disorganised speech
Disorganised or catatonic behaviour
Negative symptoms
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5
Q

How long must schizophrenic signs last for?

A

6 months (one month of active symptoms)

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6
Q

What genes are associated with schizophrenia?

A
BDNF
COMT
DAOA
Neuregulin 1
Dysbindin
DISC1
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7
Q

What are the different classes of schizophrenia?

A
Paranoid
Disorganised
Catatonic
Undifferentiated
Residual
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8
Q

What is schizophrenia associated with?

A

decreased synaptic spines

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9
Q

What is schizophrenia associated with in the cortex?

A

decreased dendritic complexity

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10
Q

What happens with regard to the mesolimbic pathway in schizophrenia?

A

hyperactivity

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11
Q

What does schizophrenia cause hypoactivity in?

A

mesocortical pathway

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12
Q

What D1 receptors are known for treatment?

A

D1 and D5

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13
Q

What D2 receptors are known for treatment?

A

D2, 3 and 4

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14
Q

Give examples of schizophrenic treatment

A

Typical antipsychotics

Atypical antipsychotics

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15
Q

How do you test for Frontal cortical dysfunction?

A

Wisconsin Card Sorting Test

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16
Q

What happens in a MRI in schizophrenia?

A

Larger ventricles and
smaller mesial temporal lobe
structures

17
Q

Where is there decreased activity in schizophrenia?

A

frontal activity

18
Q

Why does schizophrenia start?

A

abnormalities in the formation and maturation of brain circuits

19
Q

Give examples of typical antipsychotics

A
Chlorpromazine
Haloperidol
Thiorizadine
Fluphenazine
Trifluoperazine
Flupentixol
20
Q

What is the difference etween typical and atypical antipsychotics

A

Atypical antipsychotics may improve cognition

21
Q

What activity do atypicals have?

A

Antagonistic activity at 5HT2 receptors

22
Q

Give examples of atypical drugs

A
Clozapine
Olanzapine
Aripiprazole
Paliperidone
Resperidone
23
Q

What are adverse effects of treatment?

A
Extrapyramidal symptoms
Weight gain
Dyslipidaemia
T2 diabetes
Allergic reactions
Postural hypotension
Dry mouth
urinary retension
Constipation
24
Q

What is a medical emergency to do with schizophrenia?

A

Neuroleptic Malignant syndrome

25
Q

What are causes of neuroleptic malignant syndrome?

A
Hyperpyrexia
Muscle rigidity
Tremor
Confusion
Autonomic instability