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Pharmacology > SBL: Dermatology Pharm > Flashcards

SBL: Dermatology Pharm Flashcards

1
Q

What should you give for healing diabetic foot ulcers that functions as a PDGF, but also can cause cancer later on?

A

Becaplermin

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2
Q

Bacitracin is great for gram ___ organisms via inhibiting bacterial ___ synthesis.

A

Gram + organisms and it inhibits cell wall synthesis

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3
Q

Neomycin is bacteriocidal or bacteriostatic?

A

Bacteriostatic by binding 30s of gram (-) organisms

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4
Q

Polymixin B is bacteriocidal or bacteriostatic?

A

Bacteriocidal by altering permeability and damaging cell membranes

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5
Q

What can you give topically to treat vulvovaginal candidiasis?

A

Miconazole or clotrimazole

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6
Q

What can you prescribe for 48 weeks to treat onychomycosis?

A

Efinaconazole

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7
Q

What can treat topical dermatophytosis and candidiasis but is also a shampoo for seborrheic dermatitis?

A

Ketoconazole

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8
Q

This topical antifungal is broad spectrum and treats dermatophytes, candida, and malassezia. it also has a low incidence of adverse reactions

A

Ciclopirox

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9
Q

Inhibits squalene epoxidase, effective against dermatophytes but not yeasts; AVOID MUCUS MEMBRANES

A

terbanifine

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10
Q

Which antifungal stunts mycelial growth/distorts hyphae and does not work against candida?

A

Tolnaftate; only effective against dermatophytes and malessezia

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11
Q

This topical antifungal is great for oral candidiasis, but do not swallow or else diarrhea.

A

Nystatin

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12
Q

what is nystatin MOA?

A

alters membrane permeability allowing electrolytes to leak out

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13
Q

What antifungal is limited to cutaneous candida infections and can cause temporal yellow staining of skin?

A

Amphotericin B

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14
Q

This guanosine analogue is great for treating HSV 1/2 herpes labialis?

A

Acyclovir

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15
Q

What is a great Tx for anogenital pruritis?

A

Topical calcineurin inhibitors

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16
Q

Which drug activates TRPV1 to release substance P, and desensitize you to neuropathic itch?

A

Capsaicin

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17
Q

Which local anesthetic is given for facial itching in those with CKD?

A

Promoxine

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18
Q

What type of patch can be used for neuropathic itch?

A

Lidocaine

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19
Q

Rule of thumb for topical steroids?

A

High potency and titrate down on everywhere but face, genitals and body folds

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20
Q

What anti-inflammatory is found in skin products to cause epidermis to shed and dissolve epidermal cement?

A

Salicylic Acid

Watch out for sun exposure after use

21
Q

What is the a2 agoinst used to treat Rosacea

A

Briminodine gel

22
Q

What is the a1/a2 agonist used to treat rosacea

A

Oxymetazoline cream

23
Q

Which organophosphate can kill ectoparasites (lice)?

A

Malathion

24
Q

Which topical agent does not permit Na+ channels, so no repolarization?

A

Permethrin

25
Q

Which orally administered drug blocks glutamate gated Cl- channels in InVERtebrates?

A

Ivermectin

26
Q

What is last resort to kill ectoparasites (lice) due to toxicity?

A

Lindane is GABAergic

27
Q

Tx mild comedonal acne with?

A

Topical retinoid

28
Q

Tx mild mixed papular/pustular acne with?

A

Topical retinoid+topical Ab

29
Q

Tx moderate mixed papular/pustular acne with?

A

Oral ab+topical retinoid+/-BPO

30
Q

Tx moderate nodular acne with?

A

Oral ab + topical retinoid + BPO

31
Q

Tx for severe acne?

A

Oral Isotretinoin

32
Q

What treatment for acne is at risk for pseudomembranous colitis?

A

Clindamycin

33
Q

What treatment for acne is given once daily at bedtime, cause local flaking and dryness, but also has a fish allergy associated with it?

A

Tretinoin (ATRA)

34
Q

This plant defense derived dicarboxylic acid is given twice daily to treat moderate acne and post-inflammatory hyperpigmentation?

A

Azelaic acid

35
Q

Rapid fire.. all used to treat acne:

  1. Teeth discoloration and 500mg BID
  2. Photosensitivity and 50-100mg BID/150 QD
  3. Dizziness, Drug Lupus, and skin discoloration
    - EXTEDNED RELEASE
  4. Steven-Johnson Syndrome/TENS given 800mg bid
A
  1. Tetracycline
  2. Doxycycline
  3. Minocycline
  4. TMP-SMX
36
Q

This hormonal agent is used to treat menstrual cycle related breakouts?

A

Spironolactone; avoid during pregnancy

-spiral is kind of like a cycle?

37
Q

This bad boy can only be given after two negative pregnancy tests and one form of birth control. Highly effective in treating acne though.

A

Oral Isotretinoine (AKA Accutain)

38
Q

UV light therapies for psoriasis.

A

UVB=sunburns

PUVA

  • given psoralen, so watch for sun sensitivity
  • -increases risk for melanoma
39
Q

This drug inhibits PDE4, increases cAMP to decrease NO, TNF-a and then increase IL-10. Given orally to treat psoriasis and psoriatic arthritis.

A

Apremilast

ALAS, its IL-10 from Apremilast. Hazaaah

40
Q

This SubQ injection targets IL-12 and 23 to reduce CD4+, NKs to treat psoriasis, psoriatic arthritis, and Chrons?

A

Ustekinumab

41
Q

This subQ injection targets IL-17 to reduce chronic inflammation in Psoriasis, psoriatic arthritis, and ankylosing spondylitis.

A

Se-cukinumab targets IL-Se-venteen

42
Q

Wolff mentioned a couple tx for AKs.. whats the only one he went into detail about?

A

Topical 5-FU

43
Q

MOA of Topical 5FU

A

Inhibits thymidylate Synthase to cause destruction of lesions

See erythema, blistering, necrosis of lesion

44
Q

Which two drugs are used for advanced BCC?

A

Sonidegib and vismodegib

Inhibit SHH pathway

45
Q

MOA of first line treatment of alopecia?

A

Minoxidil opens K+ channels to lengthen growth phase, shorten rest phase, and enlarge follicles

46
Q

Pt is taking an oral drug for alopecia that is making him impotent.. what is he taking and why is it doing this?

A

He is taking finasteride, which inhibits DHT to increase hair count

47
Q

What are some second line tx for allopecia in women?

A

Spironlactone
Finasteride
Flutamide

48
Q

How do you manage Alopecia Areata, which is an inflammatory disorder characterized with non-scarring hair loss?

A

Corticosteroids and Diphenulcyclopropenone (DPCP)

Pharmacology (50 decks)

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