SBL: Dermatology Pharm Flashcards
What should you give for healing diabetic foot ulcers that functions as a PDGF, but also can cause cancer later on?
Becaplermin
Bacitracin is great for gram ___ organisms via inhibiting bacterial ___ synthesis.
Gram + organisms and it inhibits cell wall synthesis
Neomycin is bacteriocidal or bacteriostatic?
Bacteriostatic by binding 30s of gram (-) organisms
Polymixin B is bacteriocidal or bacteriostatic?
Bacteriocidal by altering permeability and damaging cell membranes
What can you give topically to treat vulvovaginal candidiasis?
Miconazole or clotrimazole
What can you prescribe for 48 weeks to treat onychomycosis?
Efinaconazole
What can treat topical dermatophytosis and candidiasis but is also a shampoo for seborrheic dermatitis?
Ketoconazole
This topical antifungal is broad spectrum and treats dermatophytes, candida, and malassezia. it also has a low incidence of adverse reactions
Ciclopirox
Inhibits squalene epoxidase, effective against dermatophytes but not yeasts; AVOID MUCUS MEMBRANES
terbanifine
Which antifungal stunts mycelial growth/distorts hyphae and does not work against candida?
Tolnaftate; only effective against dermatophytes and malessezia
This topical antifungal is great for oral candidiasis, but do not swallow or else diarrhea.
Nystatin
what is nystatin MOA?
alters membrane permeability allowing electrolytes to leak out
What antifungal is limited to cutaneous candida infections and can cause temporal yellow staining of skin?
Amphotericin B
This guanosine analogue is great for treating HSV 1/2 herpes labialis?
Acyclovir
What is a great Tx for anogenital pruritis?
Topical calcineurin inhibitors
Which drug activates TRPV1 to release substance P, and desensitize you to neuropathic itch?
Capsaicin
Which local anesthetic is given for facial itching in those with CKD?
Promoxine
What type of patch can be used for neuropathic itch?
Lidocaine
Rule of thumb for topical steroids?
High potency and titrate down on everywhere but face, genitals and body folds
What anti-inflammatory is found in skin products to cause epidermis to shed and dissolve epidermal cement?
Salicylic Acid
Watch out for sun exposure after use
What is the a2 agoinst used to treat Rosacea
Briminodine gel
What is the a1/a2 agonist used to treat rosacea
Oxymetazoline cream
Which organophosphate can kill ectoparasites (lice)?
Malathion
Which topical agent does not permit Na+ channels, so no repolarization?
Permethrin
Which orally administered drug blocks glutamate gated Cl- channels in InVERtebrates?
Ivermectin
What is last resort to kill ectoparasites (lice) due to toxicity?
Lindane is GABAergic
Tx mild comedonal acne with?
Topical retinoid
Tx mild mixed papular/pustular acne with?
Topical retinoid+topical Ab
Tx moderate mixed papular/pustular acne with?
Oral ab+topical retinoid+/-BPO
Tx moderate nodular acne with?
Oral ab + topical retinoid + BPO
Tx for severe acne?
Oral Isotretinoin
What treatment for acne is at risk for pseudomembranous colitis?
Clindamycin
What treatment for acne is given once daily at bedtime, cause local flaking and dryness, but also has a fish allergy associated with it?
Tretinoin (ATRA)
This plant defense derived dicarboxylic acid is given twice daily to treat moderate acne and post-inflammatory hyperpigmentation?
Azelaic acid
Rapid fire.. all used to treat acne:
- Teeth discoloration and 500mg BID
- Photosensitivity and 50-100mg BID/150 QD
- Dizziness, Drug Lupus, and skin discoloration
- EXTEDNED RELEASE - Steven-Johnson Syndrome/TENS given 800mg bid
- Tetracycline
- Doxycycline
- Minocycline
- TMP-SMX
This hormonal agent is used to treat menstrual cycle related breakouts?
Spironolactone; avoid during pregnancy
-spiral is kind of like a cycle?
This bad boy can only be given after two negative pregnancy tests and one form of birth control. Highly effective in treating acne though.
Oral Isotretinoine (AKA Accutain)
UV light therapies for psoriasis.
UVB=sunburns
PUVA
- given psoralen, so watch for sun sensitivity
- -increases risk for melanoma
This drug inhibits PDE4, increases cAMP to decrease NO, TNF-a and then increase IL-10. Given orally to treat psoriasis and psoriatic arthritis.
Apremilast
ALAS, its IL-10 from Apremilast. Hazaaah
This SubQ injection targets IL-12 and 23 to reduce CD4+, NKs to treat psoriasis, psoriatic arthritis, and Chrons?
Ustekinumab
This subQ injection targets IL-17 to reduce chronic inflammation in Psoriasis, psoriatic arthritis, and ankylosing spondylitis.
Se-cukinumab targets IL-Se-venteen
Wolff mentioned a couple tx for AKs.. whats the only one he went into detail about?
Topical 5-FU
MOA of Topical 5FU
Inhibits thymidylate Synthase to cause destruction of lesions
See erythema, blistering, necrosis of lesion
Which two drugs are used for advanced BCC?
Sonidegib and vismodegib
Inhibit SHH pathway
MOA of first line treatment of alopecia?
Minoxidil opens K+ channels to lengthen growth phase, shorten rest phase, and enlarge follicles
Pt is taking an oral drug for alopecia that is making him impotent.. what is he taking and why is it doing this?
He is taking finasteride, which inhibits DHT to increase hair count
What are some second line tx for allopecia in women?
Spironlactone
Finasteride
Flutamide
How do you manage Alopecia Areata, which is an inflammatory disorder characterized with non-scarring hair loss?
Corticosteroids and Diphenulcyclopropenone (DPCP)
