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Pharmacology > GI: Hepatitis Pharm > Flashcards

GI: Hepatitis Pharm Flashcards

1
Q

What is the contraindication of adefovir?

A

hypersensitivity

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2
Q

Would you prescribe Elbasvir/Grazoprevir in someone with cirrhosis?

A

No

-anyone with severe hepatic impairment, DO NOT prescribe

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3
Q

PEG IFN-a-2_ can treat HepB and C, while PEG IFN-a-2_ only treats HepC?

A

IFN-a-2a=HepB and C

IFN-a-2b=Hep C only

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4
Q

BB warning of tenofovir?

A

Acute exacerbations of HepB when discontinued
Lactic acidosis
Hepatomegaly and steatosis

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5
Q

What combo of drugs used to treat HepC are NS5A and NS3/4A inhibitors?

A

Elbasvir (NS5A)
and
Grazoprevir (NS3/4A)

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6
Q

What HepC drug can cause altered taste?

A

Boceprevir is associated with dysgeusia

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7
Q

What drug is a NS3/4A inhibitor used along with PEG-IFN-a and ribavirin?

A

Boceprevir

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8
Q

What drugs can cause flu like symptoms?

A

PEG IFN-a-2a and b

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9
Q

what combo of drugs to treat HepC is only used in junction with ribavirin?

A

Ledipasvir (NS5A)/Sofosbuvir (NS5B)

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10
Q

What combo of drugs causes an increase in ALT levels?

A

Elbasvir/Grazoprevir

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11
Q

What other drug is given along with ribivirin for HepC?

A

IFN-a-2a

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12
Q

What two drugs can cause renal toxicity?

A

Tenofovir and Adefovir

-so do not prescribe in those w renal issues!

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13
Q

What drugs can Elbasvir/Grazoprevir interact with?

A

Those that interfere with CYP3A

-can increase or decrease concentration

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14
Q

Would you prescribe entecavir in someone with HIV?

A

No, can make it a lot worse

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15
Q

What nucleoTide analog is used to treat HepB?

A

Adefovir

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16
Q

BB warning of entecavir?

A

Acute exacerbations of HepB when discontinued
Lactic acidosis
Hepatomegaly

17
Q

What HepC drug is severely teratogenic?

A

Ribivirn

-so pregnant mothers and husbands of pregnant mothers beware

18
Q

BB warning for Telbivudine?

A

Severe exacerbations of HepB when discontinued
Lactic acidosis
Hepatomegaly

19
Q

Both forms of PEG IFN-a are contraindicated in someone with what condition?

A

Autoimmune hepatitis

20
Q

What nucleoTide analog is used for treatment of HIV and HepB?

A

Tenofovir disoproxil

21
Q

If a patient is taking amiodarone for their heart arrythmias, what HepC drugs should you not prescribe?

A

Velpatasvir/Sofosbuvir

-potentiates bradycardia!!

22
Q

What fixed combo of HepC drugs inhibit both NS5A and NS5B?

A

Ledipasvir (NS5A)/Sofosbuvir (NS5B)

or

Velpatasvir (NS5A)/Sofosbuvir (NS5B)

23
Q

What nucleoSide analogues are used to treat HepB?

A

Entecavir and Telbivudine

24
Q

BB warning for lamivudine?

A

Acute exacerbations of HepB when discontinued
Lactic acidosis
Hepatomegaly

25
Q

What nucleoSide is used to treat HepB and HIV?

A

Lamivudine

26
Q

What can the combo of Telbivudine w PEG IFN-a-2a cuase?

A

Peripheral Neuropathy

27
Q

What drug can cause pancreatitis?

A

lamivudine

28
Q

Would you use PEG IFN-a-2a in neonates?

A

no

29
Q

What drugs should you not prescribe with Velpatasvir/Sofosbuvir?

A

Amiodarone, B-blockers

-can worsen cardiac/liver comorbidities

30
Q

What drug/drug interactions do you need to watch out for when prescribing Ledipasvir/Sofosbuvir and Velpatasvir/Sofosbuvir?

A

Poly Glycoprotein inducers (rifampin, St. Johns wart, carbamazepine)
-alter concentrations!

31
Q

What is the goal of HBV therapy?

A
  1. Supress HBV DNA
  2. Convert HBeAg from positive to neg
  3. Reduce AST/ALT
32
Q

What is the goal of HepC therapy?

A

Eradication of the virus

33
Q

Sofosbuvir inhibit what enzyme?

A

it is a NS5B polymerase inhibitor

34
Q

The NS3/4 drugs, boceprevir and grazoprevir, inhibit what enzyme?

A

They function as NS3/4 protease inhibitors

Pharmacology (50 decks)

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