Pulm: Drugs used for Influenza

Question 1

MOA of Oseltamivir, Zanamivir, and Peramivir (mivir)

Answer 1

Inhibit neuraminidase

-influenza will no longer be able to release replicated viral particles

Question 2

Indications of Oseltamivir (Tamiflu)

Answer 2

For influenza A and B in the first 48 hours

Question 3

When would oseltamivir be contraindicated?

Answer 3

Those with end stage renal disease

Question 4

Is it okay to give the influenza vaccine along with oseltamivir?

Answer 4

no, it may interfere with the vaccines effectiveness

Question 5

Is oseltamivir a substitute for the vaccine?

Answer 5

No

Question 6

ROA of oseltamivir?

Answer 6

Oral pill form

Question 7

ROA of zanamivir?

Answer 7

Powder for inhalation

Question 8

Indications for Zanamivir?

Answer 8

Influenza A and B in those who are older than 7 and have not been sick for more than 48 hours

Question 9

How is zanamivir eliminated from the body?

Answer 9

Almost exclusively by the kidneys, as an unchanged particle

Question 10

Is zanamivir the best choice for influenza in those with milk allergy?

Answer 10

No, choose oseltamivir or peramivir

Question 11

ROA of peramivir?

Answer 11

Injection

-P for perenteral

Question 12

Indications for peramivir?

Answer 12

Acute (less than 48 hours), uncomplicated flu in those who are 18+

Question 13

If pt is receiving peramivir and has renal impairment, what precautions should be taken?

Answer 13

Administer peramivir after dialysis at an adjusted dose

Question 14

MOA of Baloxavir

Answer 14

Polymerase acidic endonuclease inhibitor

Question 15

Indications for Baloxavir?

Answer 15

Acute (less than 48hrs) flu in those who are 12+

Question 16

What is Amantadines MOA?

Answer 16

interferes with the viral M2 protein

-no well understood

Question 17

What else is amantadine used to treat, besides influenza?

Answer 17

Parkinson’s when combined with L-dopa

Question 18

Does amantadine interfere with influenza A vaccine?

Answer 18

No

-can be given together

Question 19

Indications for amantadine?

Answer 19

influenza A

Question 20

What can renal impairment due to the half life of amantadine?

Answer 20

Take it from 10-14 hours to 7-10 days

Question 21

Warnings with amantidine?

Answer 21

Increases depression and suicidal thoughts

-other CNS effects (seizures)