Female Repro: MHT and SERMs/TSECs Flashcards
Describe the symptoms when MHT would be used.
Hot flashes Night sweats Vaginal Dryness Sleep disturbances Mood/Cognitive Issues Urinary incontinence
Who would estrogen alone be prescribed to?
In women WITHOUT a uterus
Who would combo estrogen and progestin be given to?
In women WITH a uterus
-decreases risk for endometrial cancer
What are the available estrogen forms?
Estradiol
Conjugated Estrogens
Esterified Estrogens
Estropipate (less common)
Describe the available progestinic drugs?
Medroxyprogesterone
Progesterone
Methyltestosterone (less common)
-more androgens
What are some net positives from estrogen use? (NOT BENEFITS)
Decreases bad cholesterol (LDL), increases good (HDL)
-lowers risk of MI/CAD
Decreases osteoclasts=less osteoporosis
What are some net negatives from estrogen use? (NOT HARMS)
Decreases ATIII and increases platelets and clotting factors
-more DVTs and strokes!
What are the overall harms to estrogen+progesterone combo? (7)
Breast Cancer Coronary Heart disease Dementia Gallbladder disease Stroke Embolisms Urinary incontinence
What are the overall benefits for estrogen+progesterone use? (3)
Decreases:
- Diabetes
- Fractures
- Colorectal cancer
What are some overall harms to estrogen only in women WITHOUT a uterus?
Dementia Gallbladder disease Stroke Embolisms Urinary incontinence
What are some overall benefits to estrogen only in women WITHOUT a uterus?
Decreases:
- Diabetes
- Fractures
- Breast cancer
Again, when is the only time you would prescribe MHT?
To treat vasomotor symptoms and vaginal changes
What age group is MHT have benefits most outweigh the risks?
Those who are 50-59
For women with vaginal symptoms only, what medications can be prescribed? (2)
Topical Estrogen
Ospemifine
What age group has lowest risk of blood clots/stroke?
Those 50-59
-see above with MOST BENEFIT
