Sartani

Question 1

Efecte mediate prin AT1

Answer 1

-vasoconstr
-elib NA
-creste secr de A si aleosteron
-creste reaba Na
-SNC-creste elib vasopresina,stim centru sete,stim simpatica
-hipertrofie cel cardiace si vasculoare(prolif si migreaza cel musc netede vasc,cresc sinteza de factori de crestere,creste sinteza matrice proteica extracel)

Question 2

Biodisponibilitate buna

Answer 2

Irbesartan

Question 3

Adm in 2 prize

Answer 3

-eprosartan
-lorasartan
-valsartan

Question 4

Indicatii

Answer 4

-HTA(toate)
-IC cu fractie de ejectie<40%-candesartan,valsartan,losartan
-post IMA daca nu poti utiliza IECA(valsartan)
-nefropatie diabetica(losartan,irbesartan,telmisartan)
-profilax sec pt scadere morbiditate la pac cu boala aterotrombotica(telmisartan)

Question 5

Losartan

Answer 5

-HTA cu hipertrofie VS pt profilax AVC
-ef antiagregant plachetar
-scade sinteza de prostaglandine
-nefropat diabetica
-excretie influentata doar de insuf hepatica

Doze
-initial 50mg la HTA, 12,5mg la IC
-intretinere 50-100mg o data sau de 2 ori pe zi mi

Question 6

Valsartan

Answer 6

-DIOVAN
-post IMA
-IC
-doze reduse la insuf hep
-aprobat pt HTA la copii peste 6 ani si la adolescenti

Question 7

Telmisartan

Answer 7

-MICARDIS
-profilax sec 80mg/zi
-nefropat diab
-sch doza in insuf hep

Question 8

Candesartan

Answer 8

-ATACAND
-ATACAND PLUS-+hidroclorotiazida
-e promedicam
-schimba doza in IR
-4-32 mg doza unica zilnica

Question 9

Irbesartan

Answer 9

-APROVEL
-nefropat diab
-nu se sch doza nici la IR,nici la IH moderate
-150-300 mg/zi o priza