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Farmacologie > Beta Blocante > Flashcards

Beta Blocante Flashcards

1
Q

Clasificare in functie de:

A

Selectivitate,afinitate pt recep,generatii

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2
Q

Beta bloc selectivi

A

Metoprolol ,atenolol

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3
Q

Beta bloc neselectivi

A

Propanolol
Sotalol
Pindolol
Nadolol

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4
Q

Efect vasodilatator mecanism si exemple de medicam

A

1.elib NO-nebivolol,celiprolol
2.bloc alfa1-labetalol,carvedilol
3.bloc canale Ca lente-betaxolol,carvedilol
4.agonist de recep beta2 adrenergici-celiprolol

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5
Q

Agonist partial

A

Pindolol
-ef bradicardizant scazut
-scade ef adrenaliza elib in efort fizic
-nu au ef la fel de bun pe prevenire evenim cardiovasc(chiar cresc la cei cu boala coronariana)
Benefic pt pac cu bradicardie si insif cardiaca

RAR UTILIZATI ACUM

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6
Q

Proprietati particulare beta bloc

A

-activit simpatomimetica intrinseca
-ef de stabilizator de menbrana(nu glaucom,da aritmii)-propanolol,carvedilol
-vasodil
-inh deiodare T4 in T3
-ef antiaritmic de clasa 3-sotalol

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7
Q

Reprezentati generatii

A

1-propanolol,pindolol
2-metoprolol,atenolol,bisoprolol
3-neselectiv-carvedilol,labetalol
-selectiv-betaxolol,nebivolol,celiprolol

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8
Q

Efecte cardiovasculare

A

-inotrop negativ
-cronotrop negativ
-batmotrop negativ
-dromotrop negativ(scade conducedea atrio-ventriculara-prelung semn PR)
-cele neselective in special initial produc o crestere a rezist periferice ,dar la utilizare cronica scad TA

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9
Q

Ef pe ap resp

A

NU LA ASTM BRONSIC(poate da bronhospasm si criza de astm prin cresterea rezistentei la fluxul aerian)
Nici selective nici neselective,nimic!

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10
Q

Efecte metabolice

A

-scade lipoliza si glicogenoliza
-la diabetici
-poate da hipoglicemie indusa de efort(nu se face glicogenoliza)
-la pac insulino-dep poate masca simptomele hipoglicemiei(simpatice)-SE PREFERA CELE SELECTICE PE BETA1!!!!
-lipoliza-tranzitor creste VLDL si scade HDL-risc mai mare de ATS(imp clinica reduce deoarece sunt tranzitorii)

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11
Q

Ef adverse

A

-pot decompensa insuf card la pacientii cu rezerva miocardica scazuta(insuf card decomp,cardiomegal)-aici se indica beta bloc cu ASI sau vasodil

-bradicardie/bloc AV (mai ales la asociete cu Verapamil)

-cronic-probl de dinamica sexuala

-senzatie de extremitati reci,sdr Raynaud

-fatigabilitate si reducere toleranta la efort

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12
Q

Intoxicatie acuta

A

Bradicardie,bloc AV-atropina si glucagon iv
Hipotensiune-izoprelina sau alfa agonisti
Convulsii-anticonvulsivante

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13
Q

Utilizare in boala coronariana ischemica

A

-pe angina cronica stabila(scade cons O2 al miocard)

-pe sdr coronarian acut-angina instab si IMA-scade consum oxigen miocard,redistribuire flux coronar,ef antiaritmic

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14
Q

Util in HTA

A

-la pac cu insuf cardiaca,aritmii,boala coronariana isch
-tahicardie,anxietate,sdr hiperkinetic
-pac tratati cu vasodil directe
-HTA perioperatorie

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15
Q

Util in insuf cardiaca

A

-NYHA 2,3,4
-stabili
-fractie de ejectie ventric stg redusa
-sub trat de fond cu IECA(sartani) si/sau diuretice
-fara contraindic la beta bloc

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16
Q

Propanolol

A

-actiune chinidinica slaba
-liposol mare
-de doua ori pe zi adm
-doza 40 sau 80 mg/zi si max 320 mg/zi
-indic hemangiom infantil,hipertiroidism,hipertens portala
-off label-tulb psihiatrice(atac panica,tulb agresive etc)

17
Q

Sotalol

A

-antiaitmic clasa 3(bloc canale K)
-inhiba repolarizare ventric
-se fol in tahiaritmii ventric si supraventric cu simpt severe
-peeventie FiA cronica dupa cardioversie
-peeventie FiA parixistica

18
Q

Generatia 1

A

Propanolol
Sotalol
Pindolol
Nadolol

19
Q

Motoprolol

A

-BETALOC
-elib rapida-tartrat
-elib prelung-succinat
-act anestezica locala scazuta
-creste supravietuirea in Insuf card-se porneste cu o doza de 12,5 mg/zi

20
Q

Bisoprolol

A

-CONCOR
-CONCOR AM(bisoprolol+amlodipina)
-LODOZ(bisoprolol+hidroclorotiazida)
-actiune de anestezic local important
-se fol pt IC CIBIS 2
-5-10mg in doza unica

21
Q

Atenolol

A

-hidrosolubil
-se acum in Insif renala(T1/2 de 8h)

22
Q

Betaxolol

A

-LOKREN
-se fol pt glaucom sI HTA

23
Q

Actiune de anestezic local

A

-carvedilol-intens
-bisoprolol -imp
-propanolol
-pindolol
-metoprolol

24
Q

Biodisponibilitate buna

A

-bisoprolol
-atenolol
-betaxolol

25
Q

Nebivolol

A

-NEBILET
-CO-NEBILET(nebivolol+hidroclorotiazida)
-pt IC(1,25-10mg/zi) ,HTA

26
Q

Carvedilol

A

-DILATREND
-actiune de blocare recep alfa
-BCC
-antioxidant
-inh prolif cel
-excretat prin fecale(nu trebuie modif doze in insuf renala)
-conc plasmatica creste cu varsta
-trat standard in IC(+diuretic,IECA)
-2x3,125 mg/zi in IC
-doze mai mari in HTA(pana la 50 mg/zi)

27
Q

Celiprolol

A

-selectiv
-elib NO
-bloc recep alfa 2
-aginist recep beta 2
-rar folosit,pt HTA

28
Q

Labetalol

A

-neselectiv
-bloc recep alfa 2
-aginist partial recep beta2
-inh recaptare neuronala a NA
-pt HTA

29
Q

Doza unica

A

-pindolol
-nadolol
-atenolol

30
Q

Efect anestezic slab

A

-propranolol
-pindolol
-metoprolol

31
Q

Liposol

A

Propranolol
Metoprolol

32
Q

Hidrosol

A

Atenolol
Pindolol

Farmacologie (23 decks)

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