Boli obstructive pulmonare

Question 1

Modif patol BPOC

Answer 1

-infl cronica-creste nr de limfocite CD8 citotox,neutrofile,macrofage(acestea det elib de subst ce det modif structurale-factori de crestere,citokine proinfl)-remodelare bronsica
-stres oxidativ ce det agravare modif fiziopat,creste mai ales in exacerbati BPOC
-dezech proteaza-antiproteaza ,duce la scadere elastina(t conjunctiv din parech pulm)—>emfizem ireversibil

Question 2

Mecan neural Astm

Answer 2

-colinergic(recel M3)-bronhospasm si hipersecr mucus(bronhii mari)

-adrenergic(recep beta 2)-bronhodil,creste secr mucus,inh elib de mediatori proinfl de pe mastocite

-NANC
-bronhidil(VIP,NO)
-bronhoconstr-subst P,neurocitokine A,B,neuropeptid CGRP

Question 3

Mod de adm medicam

Answer 3

-topic(beta 2 adrenergice, glucocort)

-inh(anticolinergice,stabilizatori de mb mastocitara)

-oral(teofilina)