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Ryan's shit list - Step 1 > Ryan's Shit list - Immuno > Flashcards

Ryan's Shit list - Immuno Flashcards

1
Q

IL-8

A

Major chemotactic factor for neutrophils; increases phagocytosis in neutrophils

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2
Q

Lectin Compliment pathway

A

Mannose or other sugars on microbe surface –> C1-Like complex

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3
Q

C3b

A

Opsonization

Clearance of immune complexes

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4
Q

C3a

A

Anaphylaxis (C3a, 4a, 5a)

Neutrophil chemotaxis

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5
Q

C4a

A

Anaphylaxis (C3a, 4a, 5a)

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6
Q

C5a

A

Anaphylaxis (C3a, 4a, 5a)

Neutrophil chemotaxis

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7
Q

Helper T cells Markers

A

TCR, CD3, CD28, CD4, CD40L

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8
Q

Cytotoxic T cells Markers

A

TCR, CD3, CD28, CD8

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9
Q

Regulatory T cells Markers

A

TCR, CD3, CD28, CD4, CD25, FOXP3

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10
Q

B Cells Markers

A

CD19, CD20, CD21, CD40, Ig(M), MHC II, B7,

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11
Q

Macrophages Markers

A

CD4, CD14 (TLR4; binds endotoxin), CD40, MHC II, B7, Fc, C3b

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12
Q

NK Cells Markers

A

CD16 (binds Fc of IgG), CD56 (unique marker)

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13
Q

Antigenic variation (3 bac, 3 virus, 1 parasite)

A 
Salmonella (2 flagella)
Borrelia recurrentis
N. Gonorrhoeae (pilus protein)
Influenza, HIV, HCV
Trypanosomes
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14
Q

Treat with Passive Ig

A

Tetanus toxin, Botulinum toxin, HBV, Varicella, Rabies virus,

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15
Q

Alternative pathway compliment (spontaneous and microbial surfaces) –>

A

C3 –> C3Bb –> C3Bb3b

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16
Q

Lectin (microbial surfaces) –>

A

C1-Like Complex –> C4b –> C4b2b –> C4b2b3b

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17
Q

Classic (antigen-antibody:IgM/G complexes)–>

A

C1 –> C4b + C2b –> C4b2b –> C4b2b3b

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18
Q

Allergic reaction

A

T1 hypersensitivity –> Urticaria, pruritis, wheezing, fever (treat with antihistamines)

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19
Q

Anaphylactic reaction

A

Severe allergic reaction: Dypnea, bronchospasm, hypotension, respiratory distress, shock

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20
Q

Anti-centromere Ab

A

Limited Scleroderma (CREST)

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21
Q

Anti-Glutamic acid decarboxylase

A

DM Type 1

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22
Q

Anti-Histone

A

Drug induced lupus

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23
Q

Anti-Jo, Anti-SRP, anti-Mi-2

A

Polymyositis, Dermatomyositis

24
Q

Anti-Mitochondrial

A

Primary Biliary Cirrhosis

25
Q

Anti-DNA Topoisomerase 1

A

Scleroderma (Diffuse)

26
Q

Anti-Smooth muscle

A

Autoimmune Hepatitis

27
Q

Anti-Ro, Anti-La

A

Sjogren syndrome

28
Q

Anti-U1-RNP (ribonuclear protein)

A

Mixed connective tissue disease

29
Q

IgA anti-endomysial, IgA anti-tissue transglutaminase

A

Celiac disease

30
Q

MPO-ANCA / p-ANCA

A

Microscopic polyangiitis, eosinophilic granulomatosis with polyangiitis (churg-strauss syndrome)

31
Q

PR3-ANCA / c-ANCA

A

Granulomatosis with polyangitis (Wegener)

32
Q

E- Selectin

A

Sialyl Lewis (Margination and rolling)

33
Q

P-Selectin

A

Sialyl Lewis (Margination and rolling)

34
Q

GlyCAM-1, CD34

A

L-Selectin (Margination and rolling)

35
Q

ICAM-1 (CD54)

A

CD11/18 Integrins (LFA-1, Mac-1) (Tight adhesion)

36
Q

VCAM-1 (CD106)

A

VLA-4 Integrin (Tight adhesion)

37
Q

PECAM-1 (CD31)

A

PECAM-1 (CD31) (Diapedesis)

38
Q

Secreted Cytokines by Macrophages

A

IL-1, IL-6, IL-8, IL-12, TNF-alpha

39
Q

Secreted cytokines by T cells

A

IL-2, IL-3

40
Q

Secreted Cytokines by Th1 Cells

A

IFN-Gamma

41
Q

Secreted Cytokines by Th2 Cells

A

IL-4, IL-5, IL-10

42
Q

HLA - A3

A

Hemochromatosis

43
Q

HLA - B27

A

Ankylosing spondylitis
Psoriasis
Arthritis of IBD
Reactive arthritis

44
Q

HLA - DQ2/DQ8

A

Celiac

45
Q

HLA - DR2

A

Multiple sclerosis
Hay fever
SLE
Goodpastures

46
Q

HLA - DR3

A

DM T1, SLE, Graves, hashimotos

47
Q

HLA - DR4

A

DM T1, Rheumatoid arthritis

48
Q

HLA - DR5

A

Pernicious anemia, Hashimotos

49
Q

Regulatory T-cell markers

A

CD3, CD4, CD25, FOXP3

50
Q

C-reactive protein

A

Opsinin; fixes compliment

51
Q

IL-6

A

stimulates acute phase reactants

52
Q

IL-5

A

Class switching to IgA; growth of eosinophils

53
Q

IL-4

A

CLass switching to IgE and IgG

54
Q

Hematopoetic stem cell marker

A

CD34

55
Q

Chediak-hegashi

A

LYST

Ryan's shit list - Step 1 (27 decks)

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