RSL - Repro - Embryology Flashcards
Sonic Hedgehog gene: Production
at base of limbs
Sonic Hedgehog gene: action
Patterning along anterior to posterior axis
Wnt-7 gene: production
At apical ectodermal ridge
Wnt-7 gene: action
Patterning along Dorsal-ventral axis
FGF gene: production
Apical ectodermal ridge
FGF gene: Action
Stimulates mitosis of underlying mesoderm –> lengthening of limb
Homeobox (Hox) genes: action
Segmentation of embryo in Craniocaudal direction. (mutations –> appendages in wrong locations)
HCG and implantation of blastocyst: Week _
1
Bilaminar disk (epiblast, hypoblast): Week _
2
Gastrulation: Week _
3
Neural tube formation: week _
4
Extremely sensitive to teratogens: Weeks _
4-8
Heart beats: week _
4
4 limbs: week_
4
Genetalia: week_
10
Embyologic origins: Lens of eye
Surface ectoderm
Embyologic origins: Sensory organs of ear
Surface ectoderm
Embyologic origins: Anal canal below pectinate line
Surface ectoderm
Embyologic origins: Oral cavity
Surface ectoderm
Embyologic origins: Parotid, sweat, mammary glands
Surface ectoderm
Embyologic origins: Oligodendrocytes
Neuroectoderm
Embyologic origins: PNS
Neural crest
Embyologic origins: Shwann cells
Neural crest
Embyologic origins: Melanocytes
Neural crest
Embyologic origins: Parafollicular (C ) cells
Neural crest
Embyologic origins: Pia and arachnoid
Neural crest
Embyologic origins: Bones of skull
Neural crest
Embyologic origins: Aorticopulmonary septum
Neural crest
Embyologic origins: Serous linings of body cavities
Mesoderm
Embyologic origins: Spleen
Mesoderm
Embyologic origins: Testes/ovaries
Mesoderm
Embyologic origins: Dermis
Mesoderm
Embyologic origins: Vagina
Mesoderm
Embyologic origins: cardiovascular structures
Mesoderm
Embyologic origins: kidneys
Mesoderm
Embyologic origins: Adrenal cortex
Mesoderm
Embyologic origins: Bone
Mesoderm
Embyologic origins: Odontoblasts
Neural crest
Embyologic origins: Astrocytes
Neuroectoderm
Embyologic origins: Ependymal cells
Neuroectoderm
Embyologic origins: Gut tube
Endoderm
Embyologic origins: most of urethra
Endoderm
Embyologic origins: Luminal epithelial derivatives
Endoderm
Embyologic origins: Liver
Endoderm
Embyologic origins: Pancreas
Endoderm
Embyologic origins: Lungs
Endoderm
Embyologic origins: Eustatian tube
Endoderm
Embyologic origins: thymus
Endoderm
Embyologic origins: Parathyroid
Endoderm
Embyologic origins: Thyroid follicular cells
Endoderm
Embryologic origins: ANS
Neural crest
Errors in morphogenesis: Disruption
secondary breakdown of previously normal tissue (amniotic band)
Errors in morphogenesis: Deformation
Extrinsic disruption; occurs after embryonic period
Errors in morphogenesis: Malformation
Intrinsic disruption; Occurs during embryonic period (3-8weeks)
Monozygotic twinings days: Dichorionic Diamnionic
0-4 days (25%) (2 cell stage)
Monozygotic twinings days: monochorionic Diamnionic
4-8 days (75%) (Morula)
Monozygotic twinings days: Monochorionic Monoamniotic
8-12 days (
Monozygotic twinings days: monochorionic monoamniotic conjoined twins
> 13 days (formed embryonic disk
Allantois –> (embryonic derivation)
Umbilical arteries and Vein
Allantois –> (adult)
Urachus
Allantois formation: week_
3
Vitelline duct obliteration: week_
7