RSL - Resp Flashcards
Structures penetrating diaphragm: T8
T8: IVC
Structures penetrating diaphragm: T10
T10: Esophagus, Vagus
Structures penetrating diaphragm: T12
T12: Aorta, Thoracic duct, Azygous vein
Common corotid bifurcation
C4
Trachea bifurcation
T4
Abdominal Aorta bifurcation
L4
Costodiaphragmatic margin: Midclavicular
8th rib
Costodiaphragmatic margin: Mid axillary
10th rib
Costodiaphragmatic margin: Lateral border of vertebral column
11/12th rib
Physiological deadspace =
Anatomical deadspace + Alveolar deadspace
Minute ventilation =
V tidal * RR
Shift from Relaxed to Taut
Cl-, H+, CO2, 2,3-BPG, temperature
Shift from Taut to relaxed
O2
Cheyne-Stokes breathing: Pattern, reason
—iI|||Ii—iI||Ii—
Due to slowed feedback from PaCO2, as well as increased sensitivity to PaCO2
Kaussumaul breathing
Large wave. Diabetic ketoacidosis
Vessels: Alveolar pressure vs. Extra Alveolar pressure per volume
TLC: High Alveolar vessel pressure / Low Extra-alveolar vessel pressure
RV: Low Alveolar vessel pressure / High Extra-alveolar vessel pressure
Charcot-leyden crystals
Eosinophils
Methemoglobin: basis
Oxidized form of Hb (Fe3+); does not bind O2 as readily. Increased affinity for cyanide
Methemoglobin: symptoms
Cyanosis and chocolate colored blood
Methemoglobinemia: treatment
Methylene blue and VItamin C
methemoglobinemia: Causes
nitrates and Benzocaine
Carboxyhemoglobin: treatment
100% O2
Alveolar gas equation
PAO2 = PiO2 - PaCO2/0.8
Pulmonary vascular resistance equation
V = QR, P(pulmonary artery)-P(left Atrium) = CO*Pulmonary resistance
Shunt
Low V/Q
Deadspace
High V/Q
Carbaminohemoglobin
CO2 bound to Hb –> Taut state
Majority of CO2 in blood is in which form
HCO3- in plasma
Homan sign
Dorsiflexion of the food –> pain
Lines of Zahn
Alternating platelets and fibrin (pale) and rbcs (red). Only found in thrombi before death
Osmium tetroxide
Stain for Fat emboli
Triad of fat embolism:
Hypoxemia, neurological disturbance, rash
Diagnosis of PE
CT pulmonary angiography for filling defects
Reid index
Thickness of gland layer / Thickness of bronchial wall (>50%)
Barrel-shaped chest
Emphasema
Curschman spirals
Shed epithelium forms whorled mucus plugs
Restrictive lung disease: A-a gradient
Normal in: Poor breathing mechanics (extrapulmonary, hypoventilation)
increased in: Interstitial lung diseases (decreased diffusing capacity)
Hypersensitivity pneumonitis:
mixed type III/IV hypersensitivity reaction to environmental antigen (alveolar)
Caplan syndrome
rheumatoid arthritis with pneumoconiosis with intrapulmonary nodules
Asbestos: location
lower lobes (supradiaphragmatic and pleural plaques)
Asbestos: Histology
Ferruginous bodies: golden brown fusiform rods resembling dumb bells
Berylliosis: Histology
Non-caseating granuloma (responds to corticosteroids)
Berylliosis: career
Aerospace
Anthracosis
asymptomatic condition in urban dwellers exposed to sooty air
Silicosis: career
Sandblasting
Silicosis: histology
Egg shell calcification on hilar lymph nodes
Scilicosis: lobes?
upper
Berylliosis: lobes?
upper
Coal-workers pneumoconiosis: lobes?
upper
Scilicosis: Sequellae
TB infection or bronchogenic carcinoma
Lung particle clearance: >10µm
Trachea trapped
Lung particle clearance: 2.5 - 10µm
Mucocilliary transport
Lung particle clearance:
Phagocytosis
Neonatal RDS: Sequelae
RIB: Therapeutic O2–> Retinopathy of prematurity, intraventricular hemorrhage, Bronchopulmonary displasia
Low O2 –> PDA, necrotizing enterocolitis
N RDS: risk factors
Prematurity, C-Section, maternal diabetes
N RDS amniotic diagnosis:
Lecithin;sphingomyelin ratio
Obesity hypoventilation syndrome
Hypoventilation during sleep –> CO2 retention during day
Pulmonary HTN: Idiopathic - mutation>
inactivating mutation in BMPR2 gene (normally -| smooth muscle proliferation)
MCC of Lobar pneumonia
S. pneumoniae, Legionella, Klebsiella
MCC of bronchopneumonia
S pneumonia, S. aureus, H. influenza,
MCC of atypical (interstitial) pneumoniae
Mycoplasma, Chlamydia, viruses (Flu, CMV, RSV, adenovirus), Legionella
Lobar pneumonia:
Intra-alveolar exudate –> consolidation. Entire lobe involvement
Bronchopneumonia
Bronchioles and adjacent alveoli involved. >1 lobe, patch involvement
Atypical pneumonia
Inflammation restricted to interstitium, >1 lobepatchy involvement. Walking pneumonia
Small Cell CA: Paraneoplastic -
Paraneoplastic: ACTH, SIADH, Lambert Eaton, Paraneoplastic myelitis/encephalitis
Small cell CA: Cell origin
Neuroendocrine Kulchitsky cells (small dark blue cells). From bronchi.
Small Cell CA: stain
chromogrammin positive