RSL - Disease associated with neoplasms

Question 1

GI:6 conditions associated with neoplasms

Answer 1

Acanthosis nigricans,
Barrett esophagus,
Chronic atrophic gastritis,
post surgical gastric remnants,
Cirrhosis,
Ulcerative colitis

Question 2

GI - Acanthosis nigricans:
Indicator of?
More commonly associated with

Answer 2

Visceral malignancy,

Insulin resistance

Question 3

GI - Barrett esophagus:

Precursor to

Answer 3

Esophageal adenocarcinoma

Question 4

GI - Chronic atrophic gastritis, post surgical gastric remnants:
Predispose to

Answer 4

Gastric adenocarcinoma

Question 5

GI - Cirrhosis:

Predisposes to

Answer 5

Hepatocellular carcinoma

Question 6

GI - Ulcerative colitis

Predisposes to

Answer 6

Colon adenocarcinoma

Question 7

Musculoskeletal & Skin:

9 conditions associated with neoplasms

Answer 7

Actinic keratosis,
Dermato- & polymyositis,
Dysplastic nevus,
Multiple seborrheic keratosis,
Paget disease of bone,
Plummer-Vinson syndrome,
Tuberous sclerosis,
Xeroderma pigmentosum,
albanism

Question 8

Musculoskeletal & Skin: Actinic keratosis

Precursor to

Answer 8

Squamous cell carcinoma of the skin

Question 9

Musculoskeletal & Skin: Dermato- & polymyositis

Predispose to

Answer 9

Visceral malignancies, particularly genitourinary

Question 10

Musculoskeletal & Skin: Dysplastic nevus

Precursor to

Answer 10

Malignant melanoma

Question 11

Musculoskeletal & Skin: Multiple seborrheic keratosis

4 malignancies

Answer 11

GI, Breast, Lung & Lymphoid malignancies

Question 12

Musculoskeletal & Skin: Paget disease of bone
Predisposes to (2)

Answer 12

2nd degree osteosarcoma & fibrosarcoma

Question 13

Musculoskeletal & Skin: Plummer-Vinson syndrome

Predisposes to

Answer 13

Squamous cell carcinoma of the esophagus

Question 14

Musculoskeletal & Skin: Tuberous sclerosis

Manifests with multiple hamartomatous (benign) tumors (3)

Answer 14

Giant cell astrocytomas,
Renal angiomyolipomas,
Cardiac rhabdomyomas
(tumors may become malignant)

Question 15

Musculoskeletal & Skin: Xeroderma pigmentosum, albanism 
Predispose to (3)

Answer 15

Squamous cell carcinoma,
Basal cell carcinoma,
Melanoma

Question 16

Hematologic:

6 conditions associated with neoplasms

Answer 16

AIDS,
Autoimmune diseases (e.g, Hashimoto thyroiditis, SLE),
Down syndrome,
Immunodeficiency,
Li-Fraumeni syndrome,
Radiation exposure

Question 17

Hematologic: AIDS
Predisposes to (2)

Answer 17

Aggressive lymphoma (non-Hodgkin),
Kaposi sarcoma

Question 18

Hematologic: Autoimmune diseases (e.g, Hashimoto thyroiditis, SLE)
Predispose to

Answer 18

Lymphoma

Question 19

Hematologic: Down syndrome

Predisposes to

Answer 19

Acute lymphocytic leukemia

Question 20

Hematologic: Immunodeficiency
Predisposes to (3)

Answer 20

Lymphoma,
Melanoma,
Renal cell carcinoma

Question 21

Hematologic: Li-Fraumeni syndrome
p53 mutation predisposes to?
4 examples?

Answer 21

Various cancer types at a young age;
Sarcoma,
Breast,
Leukemia,
Adrenal gland

Question 22

Hematologic: Radiation exposure

High risk of developing 4 cancers

Answer 22

Leukemia,
Sarcoma,
Papillary thyroid cancer,
Breast cancer