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Ryan's shit list - Step 1 > RSL - General - Oncogenes and tumor suppressors > Flashcards

RSL - General - Oncogenes and tumor suppressors Flashcards

1
Q

Gene product Associated tumor….

BCR-ABL

A

Oncogene - tyrosine kinase

CML, ALL

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2
Q

Gene product Associated tumor….

bcl-2

A

Oncogene - inhibits apoptosis

Follicular lymphomas

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3
Q

Gene product Associated tumor….

BRAF

A

Oncogene - serine/threonine kinase

Melanoma

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4
Q

Gene product Associated tumor….

c-kit

A

Oncogene - cytokine receptor

Gastrointestinal stromal tumor

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5
Q

Gene product Associated tumor….

HER2/neu (ERB-B2)

A

Oncogene - tyrosine kinase

Breast, ovarian and gastric carcinoma

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6
Q

Gene product Associated tumor….

c-myc

A

Oncogene - transcription factor

Burkitt lymphoma

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7
Q

Gene product Associated tumor….

L-myc

A

Oncogene - transcription factor

Lung tumor

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8
Q

Gene product Associated tumor….

N-myc

A

Oncogene - transcription factor

Neuroblastoma

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9
Q

Gene product Associated tumor….

ras

A

Oncogene - GTPase

Colon cancer, lung cancer, pancreatic cancer

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10
Q

Gene product Associated tumor….

ret

A

Oncogene - tyrosine kinase

MEN 2A and B

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11
Q

Gene product Associated tumor….

APC

A

Tumor suppressor gene

Colorectal cancer

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12
Q

Gene product Associated tumor….

BRCA1 and 2

A

Tumor suppressor gene - DNA repair protein

Breast and ovarian cancer

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13
Q

Gene product Associated tumor….

MEN1

A

Tumor suppressor gene

MEN type 1

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14
Q

Gene product Associated tumor….

NF1

A

Tumor suppressor gene - Ras GTPase activating protein

Neurofibromatosis type 1

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15
Q

Gene product Associated tumor….

NF2

A

Tumor suppressor gene - Merlin (schwannomin) protein

Neurofibromatosis type 2

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16
Q

Gene product Associated tumor….

CPD4

A

Tumor suppressor gene - DPC (deleted in pancreatic cancer)

Pancreatic cancer.

17
Q

Gene product Associated tumor….

DCC

A

Tumor suppressor gene

Colon cancer

18
Q

Gene product Associated tumor….

p16

A

Tumor suppressor gene - cyclin dependent kinase inhibitor 2A

Melanoma

19
Q

Gene product Associated tumor….

PTEN

A

Tumor suppressor gene

Breast cancer, prostate cancer, endometrial cancer

20
Q

Gene product Associated tumor….

Rb

A

Tumor suppressor gene - inhibits E2F; blocks G₁→ S phase

retinoblastoma and osteosarcoma

21
Q

Gene product Associated tumor….

TSC1

A

Tumor suppressor gene - Hamartin protein

Tuberous Sclerosis

22
Q

Gene product Associated tumor….

TSC2

A

Tumor suppressor gene - Tuberin protein

Tuberous Sclerosis

23
Q

Gene product Associated tumor….

ERB-B1

A

Proto-oncogene

SCC of the lung

Ryan's shit list - Step 1 (27 decks)

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