rhesus incompatibility Flashcards

1
Q

women that are rhesus D positive

A

dont need additional Rx during pregnancy

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2
Q

why do we care if a women is rhesus-D negative

A

baby may be rhesus D positive.
Baby’s blood may find way into mum’s bloodstream and then mum will produce antibodies against rhesus-D antigens

may cause haemolytic disease of newborn if subsequent pregnancies

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3
Q

women is rhesus-D negative - how can this cause haemolytic disease of newborn in subsequent pregnancies

A

anti-d antbodieis cross placenta and into fetus

if fetus rhesus positive the antibodies will attatch to and destroy RBCs

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4
Q

mainstay of management

A

prevention of sensitisation - giving IM anti-D

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5
Q

how does anti-D medication work

A

by attaching itself to rhesus-D antigens on fetal RBCs in maternal circulation and destroying them

prevents maternal immune system recognising antigen and creating antibodies

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6
Q

when are anti-D injections given routinely

A

28wjs

Birth (if baby found to be rhesus positive)

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7
Q

when should additional anti-D be given

A

any time where sensitisation may occur
e.g. APH, amniocentesis, trauma

given within 72hrs

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8
Q

Kleihauer Test

A

checks how much fetal blood has passed into the mother’s blood during a sensitisation event. This test is used after any sensitising event past 20 weeks gestation, to assess whether further doses of anti-D is required.

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