recurrent miscarriages Flashcards
1
Q
recurrent miscarriage is classed as
A
3+ consecutive misscarriages
2
Q
Ix should be initiated agter
A
3+ first trimester miscarriages
1+ second trimester miscarriages
3
Q
causes
A
idiopathic - age antiphospholipid syndrome hereditary thrombophilias uterine abnormalities parental genetic factors chronic histiocytic intervillositis chronic conditions: diabetes, thyroid, SLE
4
Q
Antiphospholipid Syndrome
A
assoc w antiphospholipid anitibodeis
blood prone to clotting - pt in hypercoaguable state
5
Q
Antiphospholipid Syndrome - reducing risk of miscarriage
A
low dose aspirin
LMWH
6
Q
key hereditary thombophilias
A
factor V leiden factor II (prothrombin) gene mutation protein S deficiency
7
Q
uterine abnormalities
A
uterine septum unicornute septum bicornuate uterus didelphic uterus cervical insufficiency fibroids
8
Q
Chronic Histiocytic Intervillositis
A
histiocytes and macrophages build up in placenta causing inflammation and adverse outcomes
9
Q
Chronic Histiocytic Intervillositis - diagnosis
A
placental histology
-infiltrates of mononuclear cells in intervillous spaces
10
Q
Ix
A
antiphospholipid antibodies
test for hereditary thrombophilias
pelvic USS
genetic testing: POC, parents
