medications in pregnancy Flashcards
NSAIDs - how do they work
block prostaglandins
prostaglandins in pregnancy
- maintain ductus arteriosus
- soften cervix
- stimulate uterine contractions
NSAIDs in pregnancy
avoided unless necessary
esp 3rd timester - can cause premature closure of ductus arteriosus + delay labour
beta blockers - which used in pregnancy
labetolol
beta blockers used in pregnancy can cause
fetal growth restriction
hypoglycaemia in neonate
bradycardia in neonate
ACEI and ARBs used in pregnancy can cause
oligohydramnios misscarriage, fetal death hypocalvaria renal failure in neonate hypotention in neonate
hypocalvaria
incomplete formation of skull bones
use of opiates in pregnancy
can cause neonatal abstinence syndrome
warfarin and pregnancy
teratogenic and so avoid
what can warfarin cause in pregnancy
fetal loss
congenital malformations
bleeding
sodium valproate + preganncy
neural tube defecs
developmental delay
Lithium and pregnancy
avoided unless other Mx failed
esp avoid 1st trimester - congenital cardiac abnormalities (ebstein’s)
if need to use monitor closely (every 4wks and weekly from 36wks)
SSRIs and pregnancy
can cross placenta
need to balance risks against benefits of treatmnt
potential risks of SSRIs
1st trimester - congenital heart defects
3rd trimester - persistant pulmonary htn
neonates can have withdrawal symptoms
Isotretinoin (Roaccutane) and pregnancy
highly teratogenic - can cause misscarriage and congenital defects
women need very reliable contraception before, during and 1mo after taking it
