Acute Fatty Liver of Pregnancy Flashcards

1
Q

when does it occur

A

3rd trimester

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2
Q

what

A

rapid accumulation of fat within hepatocytes causing acute hepatitis

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3
Q

pathophysiology

A

impaired placental processing of fatty acids due to genetic condition of fetus

fatty acids enter maternal circulation and accumulate in liver

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4
Q

which gene

A

LCHAD deficency

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5
Q

mode of inheritance

A

autosomal recessive

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6
Q

features

A
malaise
fatigue
jaundice
N&V
abdo pain 
lack appetite
ascites
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7
Q

Blood results

A
elevated liver enzymes
raised bilirubin 
raised WCC
deranged clotting 
low platelets
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8
Q

Mx

A

obstetric emergency –> prompt admission and delivery

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