Acute Fatty Liver of Pregnancy Flashcards
1
Q
when does it occur
A
3rd trimester
2
Q
what
A
rapid accumulation of fat within hepatocytes causing acute hepatitis
3
Q
pathophysiology
A
impaired placental processing of fatty acids due to genetic condition of fetus
fatty acids enter maternal circulation and accumulate in liver
4
Q
which gene
A
LCHAD deficency
5
Q
mode of inheritance
A
autosomal recessive
6
Q
features
A
malaise fatigue jaundice N&V abdo pain lack appetite ascites
7
Q
Blood results
A
elevated liver enzymes raised bilirubin raised WCC deranged clotting low platelets
8
Q
Mx
A
obstetric emergency –> prompt admission and delivery
