REVERSIBLE CELL INURY Flashcards
2 main types of reversible injury
- CELL SWELLING
- FATTY CHANGE
MOST COMMON & MOST IMPORTANT response to cellular injuries of all types. It’s an early manifestation of cell injury.
CELLULAR SWELLING
Gross appearance of cellular swelling:
ORGAN- are swelling w/ round edges
TISSUE- show slight PALOR or BULGES
in cellular swelling affected cell shows what?
- ENLARGE
- PALE CYTOPLASM
- NUCLEUS is in normal position
what is the staining characteristic of cellular swelling?
MILD- shows CLOUDY SWELLING
Vacuoles of variable size appear in cytoplasm called ?
VACUOLAR DEGENERATION
when vacuoles are severe it’s called ?
BALLOONING DEGENERATION
this imply a sick cell, reversible form of injury & adaptive change may result to cell death
DEGENERATION
it occur mostly on HYPOXIC, TOXIC, ,ETABOLIC . this is defines as abnormal accumulation of lipid within the cell.
FATTY CHANGE
- Lipids first enter the?
- as a?
- lipids are metabolized by?
- lipids are exported from the?
- HEPATOCYTES
- FREE FATTY ACIDS
- HEPATOCTES
- HEPATOCYTES
fatty acids can be synthesized from?
ACETATE
some lipids are estrified to form what?
TG - TRIGLYCERIDES
some lipids are synthesized to ?
CHOLESTEROL or PHOSPHOLIPIDS
some lipids are oxidized for energy and produce what?
KETONE BODIES
Triglycerides must be complex with a LIPID ACCEPTOR PROTEIN called?
APOPROTEIN
apoprotein form this protein to be exported.
LIPOPROTEINS
liver is diffusely what color when all cells are affected?
YELLOW
if liver is severe, liver may?
FLOAT IN FIXATIVE WATER
Histologoc appearance of fatty change:
- presence of well delineated, lipid-filled vacuoles in the cytoplasm.
- maybe single/large vacuoles (MACROVESICULAR) or multiple/small vacuoles (MICROVESICULAR)
This special stain are used to clearly seethe lipid vacuoles, it’s a frozen section w/ an oil soluble dye called?
When it stains red, it’s lipid
OIL RED O
