CELLULAR ADAPTIONS Flashcards
Dicrease in amount of tissue or Organ, and they undergo reduction in mass due to decrease in size & number of cells
ATROPHY
sample atrophy in physiologic
- postpartum uterine
- mammary gland involution
sample of atrophy in pathologic
- Disease atrophy
- denervation of atrophy
3.persistent cell injury - loss of hormonal stimulation
- aging
Mechanism and Biochemistry of atrophy
CATABOLIC PROCESS exeeds ANABOLIC PROCESS
in atrophy organelles are removed by?
AUTOPHAGOCYTOSIS
sequential mobilization in atrophy
- SUBCATENOUS FAT- first to use
- VISCERAL FAT- second to use
- BONE MARROW
this muscle are preseved at the expense of other muscle for locomotion
POSTURAL MUSCLE eg. supraspinatus m.
“increase size of an organs” due to increase in cell size without cellular proliferation
HYPERTROPHY
this muscle has remarkable capacity to undergo hypertrophy.
CARDIAC M. & SKELETAL M.
example of hypertrophy in response to work load:
- physiology- eg. EXCERCISE
- pathology- eg. enlargement of MYOCARDIAL FIBERS
example of hypertrophy in response to trophic signal.
- physiologic- uterus and mammary gland
- pathologic- MYOCARDIAL HYPERTROPHY
Mechanism and Biochemistry of hypertrophy:
ANBOLIC process exceeds CATABOLIC PROCESS
Gross: of hyopertrophy:
Tissue & organs INCREASE IN SIZE & WEIGHT NOT IN NUMBERS
Microscopic anatomy: of hypertrophy:
CELLULAR ENLARGEMENT due to increase of number in size and organelle size.
define as an increase in” number of cells” cause an increase in orgam or tissue mass
HYPERPLASIA