Reversal of Paraytics

Question 1

What is the primary action of anticholinesterase (acetylcholine esterase inhibitors) at the neuromuscular junction (NMJ)?

A) They directly inhibit acetylcholine receptors.

B) They increase the concentration of acetylcholine by binding to acetylcholine esterase.

C) They decrease acetylcholine release at the NMJ.

D) They act as direct antagonists to acetylcholine.

Answer 1

B) They increase the concentration of acetylcholine by binding to acetylcholine esterase

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Question 2

Nondepolarizing neuromuscular blockers (NMBs) act by:

A) Directly inhibiting acetylcholine.
B) Competing with acetylcholine at the receptor site.
C) Augmenting the effect of succinylcholine.
D) Increasing the concentration of acetylcholine.

Answer 2

B) Competing with acetylcholine at the receptor site.

They are indirect antagonist

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Question 3

Depolarizing NMBs, such as succinylcholine, work by:

A) Inhibiting acetylcholine at the NMJ.
B) Mimicking acetylcholine to depolarize the cell.
C) Directly blocking the receptor sites.
D) Competing with acetylcholine as an indirect antagonist.

Answer 3

B) Mimicking acetylcholine to depolarize the cell.

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Question 4

Which anticholinesterase drug is primarily used in pediatric patients?

A) Neostigmine (Prostigmin®)
B) Physostigmine (Antilirium®)
C) Edrophonium (Tensilon®)
D) Pyridostigmine (Mestinon®)

Answer 4

C) Edrophonium (Tensilon®)

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Question 5

What is the onset of action for Edrophonium?

A) 5–10 minutes
B) 1–2 minutes
C) 7–11 minutes
D) 16 minutes

Answer 5

B) 1–2 minutes

• Rapid onset.
• May reflect a presynaptic effect.
• Acetylcholine release.

Fast Eddy

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Question 6

Which of the following statements are true regarding Edrophonium’s duration of action? (Select 3 that apply)

A) Edrophonium has a duration of action of 5–20 minutes.
B) Larger doses of Edrophonium can last up to 60 minutes.
C) If a larger dose is needed, Neostigmine should be used instead.
D) Edrophonium lasts 40–90 minutes.
E) Edrophonium is the preferred agent for prolonged muscle relaxation.

Answer 6

A) Edrophonium has a duration of action of 5–20 minutes

B) Larger doses of Edrophonium can last up to 60 minutes

C) If a larger dose is needed, Neostigmine should be used instead

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Question 7

Which of the following anticholinesterase drugs is most commonly used in clinical settings?

A) Edrophonium (Tensilon®)
B) Neostigmine (Prostigmin®)
C) Pyridostigmine (Mestinon®)
D) Physostigmine (Antilirium®)

Answer 7

B) Neostigmine (Prostigmin®)

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Question 8

What is the onset time for Neostigmine?

A) 1–2 minutes
B) 5–10 minutes
C) 7–11 minutes
D) 15–20 minutes

Answer 8

C) 7–11 minutes

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Question 9

What is the duration of action for Neostigmine?

A) 10–20 minutes
B) 20–40 minutes
C) 40–60 minutes
D) 60–90 minutes

Answer 9

C) 40–60 minutes

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Question 10

Which anticholinesterase drug is rarely used unless Neostigmine is unavailable?

A) Edrophonium (Tensilon®)
B) Neostigmine (Prostigmin®)
C) Physostigmine (Antilirium®)
D) Pyridostigmine (Mestinon®)

Answer 10

D) Pyridostigmine (Mestinon®)

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Question 11

What is the onset time for Pyridostigmine?

A) 5 minutes
B) 11 minutes
C) 16 minutes
D) 20 minutes

Answer 11

C) 16 minutes

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Question 12

What is the duration of action for Pyridostigmine?

A) 40 minutes
B) 60 minutes
C) 90 minutes
D) 120 minutes

Answer 12

C) 90 minutes

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Question 13

Which anticholinesterase drug is typically used at home and not in clinical settings?

A) Edrophonium (Tensilon®)
B) Neostigmine (Prostigmin®)
C) Physostigmine (Antilirium®)
D) Pyridostigmine (Mestinon®)

Answer 13

C) Physostigmine (Antilirium®)

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Question 14

dose of neostigmine
A. 0.01-0.04mg/kg
B.0.03-0.04mg/lk
C.0.07-0.09mg/kg
D. 0.04-0.07mg/kg

Answer 14

D. 0.04-0.07mg/kg