Paralytics: Rocuronium / Zemuron

Question 1

What is the 2 x ED95 dose of Rocuronium?

A) 0.1 mg/kg
B) 0.3 mg/kg
C) 0.6 mg/kg
D) 1.2 mg/kg

Answer 1

C) 0.6 mg/kg

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Question 2

Which of the following characteristics is true for Rocuronium?

A) Highly potent with a slow onset
B) Less potent with a faster onset
C) Highly potent with a fast onset
D) Less potent with a slow onset

Answer 2

B) Less potent with a faster onset

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Question 3

Rocuronium sets up in approximately how many minutes?

A) 1 minute
B) 2 minutes
C) 5 minutes
D) 10 minutes

Answer 3

B) 2 minutes

Memory Trick: “We will ROC you in 2 minutes”

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Question 4

What is the recommended RSI (Rapid Sequence Induction) dose of Rocuronium?

A) 0.1 mg/kg
B) 0.3 mg/kg
C) 0.6 mg/kg
D) 1.2 mg/kg

Answer 4

D) 1.2 mg/kg

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Question 5

For Rapid Sequence Induction (RSI), Rocuronium achieves onset in approximately how long?

A) 30 seconds
B) 1 minute
C) 2 minutes
D) 5 minutes

Answer 5

B) 1 minute

Memory Trick: “This RSI will ROC in 1 minute”

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Question 6

What is the recommended dose of Rocuronium following the administration of Succinylcholine (Sux)?

A) 0.1 mg/kg
B) 0.2 mg/kg
C) 0.3 mg/kg
D) 0.5 mg/kg

Answer 6

C) 0.3 mg/kg

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Question 7

What is the recommended infusion rate for Rocuronium?

A) 1-3 mcg/kg/min
B) 5-12 mcg/kg/min
C) 15-20 mcg/kg/min
D) 20-25 mcg/kg/min

Answer 7

B) 5-12 mcg/kg/min

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Question 8

What is the concentration of Rocuronium when supplied?

A) 1 mg/cc
B) 5 mg/cc
C) 10 mg/cc
D) 20 mg/cc

Answer 8

C) 10 mg/cc

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Question 9

Which of the following are true about Rocuronium’s metabolism and excretion? (Select 3 that apply)

A) It has no active metabolites.
B) It is excreted unchanged by the kidneys.
C) It is excreted unchanged in bile.
D) It undergoes significant hepatic metabolism.
E) It is metabolized primarily in the liver.

Answer 9

A) It has no active metabolites

B) It is excreted unchanged by the kidneys

C) It is excreted unchanged in bile.

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Question 10

Rocuronium is not affected by ___ failure but shows moderate prolongation in ___ failure.

A) Renal, Liver
B) Liver, Renal
C) Cardiac, Renal
D) Hepatic, Cardiac

Answer 10

A) Renal, Liver

not affected by renal failure
shows moderate prolongation in liver failure

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Question 11

In which of the following situations might Rocuronium be slightly prolonged? (Select 2 that apply)
A) Liver failure
B) Elderly patients
C) Pregnancy
D) Acute renal failure

Answer 11

B) Elderly patients
C) Pregnancy

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Question 12

Put it all together

1. The dose for 2 x ED95 of Rocuronium is ___ mg/kg.
2. Its lower potency results in a faster onset, setting up in approximately ___ minutes.
3. Rocuronium’s dose for rapid sequence induction (RSI) is ___ mg/kg.
4. Rocuronium sets up in ___ minute(s) after administration.
5. After succinylcholine, the dose of Rocuronium is ___ mg/kg.
6. The infusion rate for Rocuronium is ___ mcg/kg/min.
7. Rocuronium is supplied as __ mg/cc.
8. Rocuronium has minimal to no metabolism and is excreted unchanged by the ___ and in ___.
9. Rocuronium is not affected by ___ failure but shows moderate prolongation in ___ failure.
10. Rocuronium is slightly prolonged in ___ and ___.

Answer 12

1. 0.6 mg/kg
2. 2 minutes
3. 1.2 mg/kg
4. 1 minute
5. 0.3 mg/kg
6. 5 –12 mcg/kg/min
7. 10 mg/cc
8. kidneys, bile
9. renal, liver
10. elderly, pregnancy

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