Opioid Antagonist - Naloxone / Narcan

Question 1

Naloxone (Narcan) acts as an antagonist at which of the following opioid receptors?

A) Mu only
B) Kappa only
C) Delta only
D) Mu, kappa, and delta

Answer 1

D) Mu, kappa, and delta

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Question 2

Naloxone is primarily used for:

A) Increasing opioid effectiveness
B) Reversing respiratory depression caused by opioids
C) Prolonging the effects of opioids
D) Treating non-opioid induced pain

Answer 2

B) Reversing respiratory depression caused by opioids

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Question 3

The recommended intravenous dose range of Naloxone for reversing respiratory depression is:

A) 10-20 mcg
B) 20-40 mcg
C) 40-80 mcg
D) 80-120 mcg

Answer 3

C) 40-80 mcg IV

Corn: give 40 mcg at a time

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Question 4

Naloxone is typically supplied in what concentration, which often requires dilution before administration?

A) 40 mcg/ml
B) 100 mcg/ml
C) 400 mcg/ml
D) 1000 mcg/ml

Answer 4

C) 400 mcg/ml

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Question 5

Naloxone can cause ________ stimulation due to the abrupt reversal of analgesia.

A) Respiratory
B) Cardiac
C) Neurological
D) Gastrointestinal

Answer 5

B) Cardiac

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Question 6

What is a potential serious side effect of abrupt reversal of analgesia with Naloxone?

A) Hypertension
B) Flash pulmonary edema
C) Respiratory depression
D) Bradycardia

Answer 6

B) Flash pulmonary edema

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Question 7

Which of the following mu side effects can Naloxone help reduce or reverse? (Select 4 that apply)

A) Pruritus
B) Urinary retention
C) Muscle rigidity
D) Biliary spasm
E) Hypertension
F) Sedation

Answer 7

A) Pruritus
B) Urinary retention
C) Muscle rigidity
D) Biliary spasm

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Question 8

Why is it important to remain vigilant after administering Naloxone to reverse the effects of a narcotic?

A) Naloxone permanently reverses the narcotic effects.
B) Naloxone can wear off before the narcotic, risking the return of symptoms.
C) Naloxone enhances the effects of narcotics over time.
D) Naloxone has a longer duration than most narcotics.

Answer 8

B) Naloxone can wear off before the narcotic, risking the return of symptoms.

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Question 9

put it all togeher

1. Naloxone is an opioid antagonist that acts on the ___ , ___ , and ___ opioid receptors.
2. The typical dose range of Naloxone for reversing respiratory depression is ___ to ___ mcg IV.
3. Naloxone is supplied at a concentration of ___ mcg/ml and must be ___ before administration.
4. One potential side effect of rapid analgesia reversal with Naloxone is ___ stimulation.
5. Naloxone carries a risk of causing flash ___ edema as a severe side effect.
6. Naloxone can reduce or reverse side effects associated with mu receptors, including ___ , ___ retention, muscle ___, and biliary ___.
7. Because Naloxone can wear off before the ___, it is essential to remain ___ when monitoring the patient.

Answer 9

1. mu, kappa, delta
2. 40 to 80 mcg IV
3. 400 mcg/ml, diluted
4. cardiac
5. pulmonary edema
6. pruritis, urinary retention, muscle rigidity, biliary spasm
7. narcotic, vigilant

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Question 10

Onset of Naloxone is
A.1-3min
B.1-5 min
C.2-3min
D.4-6min

Answer 10

B. 1-5min

Question 11

duration of Naloxone is
A.90min
B.15 min
C.60 min
D.30 min

Answer 11

D. 30min