Narcotics: Morphine

Question 1

Morphine is classified as an __________, meaning it binds to and activates opioid receptors.

A) Antagonist
B) Agonist
C) Antihistamine
D) Enzyme

Answer 1

B) Agonist

Throw back to Dr. T

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Question 2

What is the typical IV dose range for Morphine when used for post-operative pain management?

A) 1-5 mg
B) 5-20 mg
C) 20-30 mg
D) 10-40 mg

Answer 2

B) 5-20 mg titrated

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Question 3

After intrathecal administration, Morphine can cause delayed respiratory depression lasting up to __________ hours.

A) 6
B) 12
C) 18
D) 24

Answer 3

D) 24

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Question 4

Morphine has dose-dependent release of which chemical that may lead to side effects?

A) Epinephrine
B) Dopamine
C) Histamine
D) Serotonin

Answer 4

C) Histamine

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Question 5

With high doses, Morphine can lead to a decrease in __________.

A) PVR
B) Heart rate
C) Respiratory rate
D) Blood pressure

Answer 5

B) Peripheral vascular resistance (PVR)

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Question 6

In patients with liver failure, renal failure, or advanced age, Morphine’s half-life is:

A) Shortened
B) Unaffected
C) Prolonged
D) Doubled

Answer 6

C) Prolonged

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Question 7

True or False

Morphine has 2 active metaboiltes

Answer 7

True

Morphine-6-glucuronide (M6G)
More potent than morphine and is responsible for the analgesic effect of morphine

Morphine-3-glucuronide (M3G)
An inactive metabolite that may produce excitatory effects and is responsible for some side effects of high-dose morphine

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