Paralytics: Vecuronium / Norcuron

Question 1

Vecuronium is classified as which type of compound?

A) Di-quaternary am

Answer 1

B) Monoquaternary aminosteroid

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Question 2

What is the 2x ED95 dose for Vecuronium?

A) 0.05 mg/kg
B) 0.1 mg/kg
C) 0.2 mg/kg
D) 1 mg/kg

Answer 2

B) 0.1 mg/kg

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Question 3

After using Succinylcholine, what dose of Vecuronium is typically administered?

A) 0.1 mg/kg
B) 0.05 mg/kg
C) 1 mg/kg
D) 0.5 mg/kg

Answer 3

B) 0.05 mg/kg

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Question 4

What is the typical infusion rate for Vecuronium?

A) 0.5–1 mcg/kg/min
B) 1–2 mcg/kg/min
C) 2–3 mcg/kg/min
D) 5–10 mcg/kg/min

Answer 4

B) 1–2 mcg/kg/min

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Question 5

Why is Vecuronium not considered the best choice for infusion?

A) It has a rapid onset.
B) It does not accumulate in the body.
C) It may accumulate due to hepatic metabolism.
D) It is metabolized by the kidneys.

Answer 5

C) It may accumulate due to hepatic metabolism.

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Question 6

Vecuronium is supplied as a powder and is mixed with water to make a concentration of:

A) 1 mg/cc
B) 2 mg/cc
C) 0.5 mg/cc
D) 10 mg/cc

Answer 6

A) 1 mg/cc

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Question 7

What percentage of Vecuronium’s metabolism is hepatic?

A) 20-30%
B) 30-40%
C) 50-60%
D) 70-80%

Answer 7

B) 30-40%

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Question 8

What are the properties of Vecuronium’s metabolism and effects (select 3 that apply)?
A) It has an active metabolite.
B) It retains 80% potency of the parent compound.
C) It may accumulate in renal failure.
D) It has no active metabolites.
E) It is excreted entirely by the lungs.

Answer 8

A) It has an active metabolite

B) It retains 80% potency of the parent compound

C) It may accumulate in renal failure.

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Question 9

Put it all together

1. Vecuronium is classified as a ___
2. Vecuronium’s 2 x ED95 dose is ___ mg/kg.
3. The dosing of Vecuronium after Succinylcholine is ___ mg/kg.
4. The infusion rate for Vecuronium is __ mcg/kg/min.
5. Vecuronium may not be suitable for continuous infusion because of ___.
6. Vecuronium is supplied as a powder that needs to be mixed with water to create ___ mg/cc.
7. Vecuronium undergoes hepatic metabolism, with approximately ___% of it metabolized by the liver.
8. Vecuronium’s active metabolite retains ___% potency of the parent compound.
9. Vecuronium may accumulate in patients with ___ failure.

Answer 9

1. monoquaternary aminosteroid
2. 0.1 mg/kg
3. 0.05 mg/kg
4. 1–2 mcg/kg/min
5. accumulation
6. 1 mg/cc
7. 30–40%
8. 80%
9. renal failure

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