Paralytics: Cisatracurium / Nimbex

Question 1

Cisatracurium (Nimbex) is an isomer of Atracurium and is ________ times more potent.

A) 2
B) 3
C) 4
D) 5

Answer 1

C) 4

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Question 2

Which of the following is true regarding Cisatracurium (Nimbex)?

A) It causes significant histamine release.
B) It causes mild histamine release.
C) It does not release histamine.
D) It releases histamine only in high doses.

Answer 2

C) It does not release histamine.

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Question 3

**need to verify this with lecture

Cisatracurium (Nimbex) shows little change in efficacy with which of the following factors? (Select 2 that apply)
A) Age
B) Liver disease
C) Illness severity
D) Gender

Answer 3

A) Age

C) Illness severity

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Question 4

What is one of the advantages of Cisatracurium (Nimbex) in terms of drug accumulation?

A) It accumulates rapidly in the body.
B) It accumulates slowly, which is beneficial for long-term use.
C) It does not accumulate.
D) It only accumulates in the kidneys.

Answer 4

C) It does not accumulate.

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Question 5

The dosing for Cisatracurium (Nimbex) is often based on multiples of ED95. What is the dose of Cisatracurium if it is administered at 2 x ED95?

A) 0.1 mg/kg
B) 0.2 mg/kg
C) 0.5 mg/kg
D) 1 mg/kg

Answer 5

B) 0.2 mg/kg

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Question 6

What is the recommended dose of Cisatracurium (Nimbex) after administering Succinylcholine?

A) 0.05 mg/kg
B) 0.1 mg/kg
C) 0.15 mg/kg
D) 0.2 mg/kg

Answer 6

B) 0.1 mg/kg

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Question 7

What is the recommended infusion rate for Cisatracurium (Nimbex)?

A) 0.5 – 1 mcg/kg/min
B) 1 – 2 mcg/kg/min
C) 2 – 3 mcg/kg/min
D) 3 – 4 mcg/kg/min

Answer 7

B) 1 – 2 mcg/kg/min

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Question 8

What is the concentration of Cisatracurium (Nimbex) as supplied in vials?
A) 1 mg/cc
B) 2 mg/cc
C) 5 mg/cc
D) 10 mg/cc

Answer 8

B) 2 mg/cc

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Question 9

How should Cisatracurium (Nimbex) be stored?

A) At room temperature
B) In the refrigerator
C) In the freezer
D) In a dark room

Answer 9

B) In the refrigerator

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Question 10

What are true about Nimbex (Cisatracurium) (Select 2 that apply)?

A) It is metabolized by the liver, avoiding kidney involvement.
B) It is metabolized in the blood, making it organ-independent.
C) It is excreted directly by the kidneys without modification.
D) It does not accumulate in patients with renal failure.
E) It releases minimal histamine, reducing cardiovascular side effects.

Answer 10

B) It is metabolized in the blood, making it organ-independent.

D) It does not accumulate in patients with renal failure.

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Question 11

Which of the following statements is true about Cisatracurium (Nimbex)?

A) It is inexpensive and widely available.
B) It is relatively inexpensive but requires frequent dosing.
C) It is expensive compared to other paralytics.
D) It is only used in emergency situations.

Answer 11

C) It is expensive compared to other paralytics.

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Question 12

Put it all together

1. Cisatracurium (Nimbex) is an isomer of __ and is __ times more potent.
2. Cisatracurium (Nimbex) does not release ___.
3. Cisatracurium (Nimbex) shows __ change with age or illness.
4. Cisatracurium (Nimbex) does not ___, making it suitable for prolonged infusions.
5. –
6. The recommended dose of Cisatracurium (Nimbex) after succinylcholine is ___ mg/kg.
7. The typical infusion rate for Cisatracurium (Nimbex) is __ to __ mcg/kg/min.
8. The concentration of Cisatracurium (Nimbex) as supplied is __ mg/cc.
9. Cisatracurium (Nimbex) should be stored in the ___.
10. Cisatracurium (Nimbex) is particularly useful for patients with ___ dysfunction due to its unique metabolism in the blood.
11. Cisatracurium (Nimbex) is known to be ____-independent
12. Cisatracurium (Nimbex) is generally more ___ compared to other paralytic agents

Answer 12

1. Atracurium, 4 times
2. Histamine
3. little
4. accumulate
5. 0.2 mg/kg
6. 0.1 mg/kg
7. 1 to 2 mcg/kg/min
8. 2 mg/cc
9. refrigerator
10. renal
11. organ - independent
12. expensive

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