Induction Agent: Propofol Flashcards
What is the generic name of the drug commonly known as Diprivan?
A) Midazolam
B) Fentanyl
C) Propofol
D) Ketamine
C) Propofol
Slide 9
Which of the following are NOT uses of Propofol?
A) IV induction of anesthesia
B) Maintenance of anesthesia with TIVA
C) Long-term sedation in elderly patients
D) Management of PONV
C) Long-term sedation in elderly patients
Slide 9
What is the standard concentration of Propofol used for anesthesia?
A) 1 mg/cc
B) 5 mg/cc
C) 10 mg/cc
D) 20 mg/cc
C) 10 mg/cc
(20cc vial standard). 1% lipid solution
Slide 11
The typical induction dose of Propofol for an adult is:
A) 0.5 mg/kg IV
B) 1 mg/kg IV
C) 2 mg/kg IV
D) 3 mg/kg IV
C) 2 mg/kg IV
Slide 11
For sedation, the dose range of Propofol is:
A) 25–100 mcg/kg/min
B) 50–200 mcg/kg/min
C) 100–300 mcg/kg/min
D) 10–50 mcg/kg/min
A) 25–100 mcg/kg/min
Slide 11
What is the typical dose range of Propofol for Total Intravenous Anesthesia (TIVA)?
A) 10–50 mcg/kg/min
B) 25–75 mcg/kg/min
C) 100–300 mcg/kg/min
D) 400–600 mcg/kg/min
C) 100–300 mcg/kg/min
Slide 11
True or False
Propofol is a controlled substance
False
A pretreatment with __________ can help reduce pain on injection with Propofol.
A) 1–2% Lidocaine
B) 0.5% Bupivacaine
C) Fentanyl
D) Midazolam
A) 1–2% Lidocaine
Slide 11
Which of the following statements are true about Propofol’s pharmacokinetics?
Select 3
A) It has a high protein-binding capacity
B) It always requires dose adjustments in patients with renal or liver disease.
C) It is highly accumulative with short-term use.
D) The patient is unconscious within 30 seconds of administration.
E) Propofol is a titratable drug
F) Increased dose for elderly patients
A) It has a high protein-binding capacity (98%)
D) The patient is unconscious within 30 seconds of administration.
E) Propofol is a very titratable drug
Doses rarely need to be changed with renal or liver disease.
Accumulates with long therapy.
Slide 11
The context-sensitive half-time of Propofol is __________, does accumulate with long therapy.
A) >20 minutes
B) >30 minutes
C) >40 minutes
D) >60 minutes
C) >40 minutes
Slide 11
Propofol’s elimination half-life ranges between:
A) 0.5 to 1.5 hours
B) 2 to 4 hours
C) 5 to 7 hours
D) 8 to 12 hours
A) 0.5 to 1.5 hours
Slide 11
Which of the following is an additional benefit of Propofol aside from its sedative properties?
A) Bronchodilation
B) Vasoconstriction
C) Muscle relaxation
D) Anticoagulant effects
A) Bronchodilation
Slilde 12
Propofol is considered the best drug to blunt the laryngeal response during which procedure?
A) Endoscopy
B) Bronchoscopy
C) Laryngoscopy
D) Colonoscopy
C) Laryngoscopy
Slide 12
In low doses, Propofol can be used as a rescue medication to treat __________.
A) Hypertension
B) Bradycardia
C) PONV
D) Hypotension
C) PONV Postoperative nausea and vomiting
Slide 12
Propofol Infusion Syndrome
Rare problems with Propofol are normally caused by:
Select 3
A) High-dose Propofol infusion (≥ 5 mg/kg/hr)
B) Short-term use in minor surgeries
C) Use in critically ill patients with head injuries
D) Low-dose Propofol infusion ( < 5 mg/kg/hr)
E) Extended infusion duration (> 58 hours)
A) High-dose Propofol infusion (≥ 5 mg/kg/hr)
C) Use in critically ill patients with head injuries
E) Extended infusion duration (> 58 hours)
Critically ill adults with head injuries receiving long term (> 58 hours) and high dose infusions (5 mg/kg/hr)
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