RETRO, CALICI, REO, ORTHOYXO, FILO Flashcards
Icosahedral, enveloped virion
RETROVIRIDAE
80-130 nm
RETROVIRIDAE
Contain an RNA-dependent DNA polymerase for replication - Reverse transcription
RETROVIRIDAE
Genus: Lentivirus
RETROVIRIDAE
2 virus: HIV and HTLV 1 and 2
Genera: Norovirus, Sapovirus, Lagovirus, Vesivirus
CALICIVIRIDAE
Small, naked virus
CALICIVIRIDAE
HUMAN IMMUNODEFICIENCY VIRUS
RETROVIRIDAE
HUMAN T-LYMPHOCYTROPIC VIRUS (HTLV)
RETROVIRIDAE
NORWALK VIRUS
CALICIVIRIDAE
By by Luc Montagnier (1983)
HUMAN IMMUNODEFICIENCY VIRUS
- Simian Virus: acquired from monkeys
HUMAN IMMUNODEFICIENCY VIRUS
: causes Acquired Immunodeficiency Syndrome
HIV-1
: restricted in West Africa
HIV-2
isolated by Robert Gallo in 1981
HUMAN T-LYMPHOCYTROPIC VIRUS (HTLV)
: causes adult acute T-cell lymphocytic leukemia, HTLV-I-associated myelopathy/tropical spastic paraparesis
HTLV-1
: linked to neurological disease
HTLV-2
- Not associated w/ malignancies
HTLV-2
first studied from an epidemic of diarrhea in Norwalk, Ohio
NORWALK VIRUS
body fluids
sexual intercourse
parenteral (sharing of needles)
transfusion and organ transplantation
vertical transmission
HUMAN IMMUNODEFICIENCY VIRUS
sexual intercourse
parenteral
transfusion
HUMAN T-LYMPHOCYTROPIC VIRUS (HTLV)
ingestion
- highly contagious
- gastroenteritis in adults and elderly
CALICIVIRIDAE
lymphadenopathy and fever
opportunistic infections
malignancies
wasting
AIDS
dementia
- Weight loss, malaise
- Pneumocystis carinii (pneumonia)
- Herpes, diarrhea
- Alzheimer’s disease
HUMAN IMMUNODEFICIENCY VIRUS
- Antiretroviral therapy: increases CD4 value of
HUMAN IMMUNODEFICIENCY VIRUS
o: normal
o: with HIV
400
<200
AIDS was first described on June 5, 1981
HUMAN IMMUNODEFICIENCY VIRUS