7-SYSTEMIC FUNGI Flashcards
MOT:
inhalation of spores (mold)
Specimen:
Sputum
contains HEPA filter
BSL III=BSC class II
No
person-to-person contact
Colonies:
cottony white to brown
blastomycosis/Gilchrist disease
Blastomyces dermatitidis
chronic granulomatous and suppurative infection of the lungs, skin and mucous membranes
Blastomyces dermatitidis
Primary Lung
Blastomyces dermatitidis
Chronic skin-bone
Blastomyces dermatitidis
Slow to moderate growers
Blastomyces dermatitidis
Rapid growers (3 to 4 days)
Blastomyces dermatitidis
Dipmorphic
Coccidioides immitis
habitat: soil
Coccidioides immitis
Paracoccidioides brasiliensis
habitat: alkaline soil
Histoplasma capsulatum
coccidioidomycosis/Valley fever
Coccidioides immitis
Asymptomatic pulmonary disease
Coccidioides immitis
skin infections are characterized by erythema nodosum and multiforme and arthritis
Coccidioides immitis
Symptomatic: fever, respiratory distress, cough, anorexia, headache, malaise, and myalgias
Coccidioides immitis
most virulent human mycosis
Coccidioides immitis
histoplasmosis
Histoplasma capsulatum
coin lesions, flattened lesions in lungs
Histoplasma capsulatum
very fatal and may lead to death to immunodeficient/ immunosuppressed patient
Histoplasma capsulatum
Acquired in bird poops, bat guanos/ bat poops
Histoplasma capsulatum
“Cave’s disease”
Histoplasma capsulatum
Specimen: blood, urine, CSF
Histoplasma capsulatum
Paracoccidiodomycosis
Paracoccidioides brasiliensis
South American blastomycosis
Paracoccidioides brasiliensis
Brazilian blastomycosis
Paracoccidioides brasiliensis
Lutz-Splendore-Almeida disease
Paracoccidioides brasiliensis
paracoccidioidal granuloma
Paracoccidioides brasiliensis
lung infection
Paracoccidioides brasiliensis
asymptomatic and self- limiting
Paracoccidioides brasiliensis
spelunker’s disease
Histoplasma capsulatum
Darling’s disease (pulmonary disease)
Histoplasma capsulatum
cave disease
Histoplasma capsulatum
reticuloendothelial cytomycosis
Histoplasma capsulatum
not common
Paracoccidioides brasiliensis
Endemic in Mississippi and Ohio river valleys
Blastomyces dermatitidis
Endemic in Southwest United States (Mexico), Central and South America
Coccidioides immitis
Endemic in Ohio, Missouri, Mississippi river valleys
Histoplasma capsulatum
Endemic in Central and South America
Paracoccidioides brasiliensis
Culture Media: Blood agar
Blastomyces dermatitidis
White to dark tan; young colonies tenacious, older colonies glabrous to woolly
Blastomyces dermatitidis
Culture: 22oC
Coccidioides immitis
White to tan to dark gray
Coccidioides immitis
Young colonies tenacious, older colonies cottony
Coccidioides immitis
Culture: pines medium, glucose-cysteine blood, or BHI with blood agar
Histoplasma capsulatum
White to brownish mold
Histoplasma capsulatum
Woolly, cottony, or granular
Histoplasma capsulatum
BHI with blood agar- confirmatory test for Histoplasma capsulatum (grow under 37oC)
Histoplasma capsulatum
Wright’s-Giemsa for capsule
Histoplasma capsulatum
White to beige; colony glabrous, leathery, flat to wrinkled, folded, or velvety
Paracoccidioides brasiliensis
Hyphae: fine hyaline septate hyphae
Blastomyces dermatitidis
Conidia: lollipop in appearance, borne directly from the hyphae or on conidiophores
Blastomyces dermatitidis
Yeast: large yeast (8-12 um) o resembles the figure 8
Blastomyces dermatitidis
Daughter cell is attached by broad necks
Blastomyces dermatitidis
Hyphae: septate hyaline with varying widths
Coccidioides immitis
Conidia: arthroconidia (barrel shaped)
Coccidioides immitis
Tissue form: spherules (30-60 um) containing endospore
Coccidioides immitis
Hyphae: very fine septate hyaline hyphae
Histoplasma capsulatum
Macroconidia: sunflower in bloom; large unicellular, spherical with tuberculate walls
Histoplasma capsulatum
Microconidia: borne directly or in short conidiophores
Histoplasma capsulatum
Yeast form: blastoconidia with narrow necks
Histoplasma capsulatum
Hyphae: same with Coccidiodes
Paracoccidioides brasiliensis
Conidia: not common
Paracoccidioides brasiliensis
Yeast: mariner’s wheel
Paracoccidioides brasiliensis