FLAVIVIRIDAE, RHABDOVIRIDAE, TOGAVIRIDAE Flashcards
1
Q
Break-bone fever
A
Dengue Fever Virus
2
Q
● Enveloped and icosahedral with a single stranded ,positive sense RNA genome
A
ZIKA VIRUS
3
Q
ZIKA VIRUS
● First Isolated from (?) in the Zika Forest of Uganda
A
Rhesus Macaque
4
Q
● Positive sense single stranded RNA virus
A
WEST NILE VIRUS
5
Q
● This can cause Encephalitis
A
WEST NILE VIRUS
6
Q
WEST NILE VIRUS
● First discovered in the ―West Nile ― province of Uganda in
A
1937
7
Q
● A single-stranded
A
JAPANESE AND ST. LOUIS ENCEPHALITIS VIRUS
8
Q
● RNA virus, enveloped
A
JAPANESE AND ST. LOUIS ENCEPHALITIS VIRUS
9
Q
● Bites of infected mosquito
A
Yellow Fever Virus
10
Q
Yellow Fever Virus 3 Types of transmission cycle
A
● Sylvatic (or jungle) yellow fever
● Intermediate yellow fever
● Urban yellow fever
11
Q
Bite of an infected Aedes species (Ae. aegypti or Ae. albopictus) mosquito
A
Dengue Fever ViruS
12
Q
Mosquito ( Aedes aegypti and Aedes albopictus)
A
Dengue Fever Viru
ZIKA VIRUS
13
Q
● Vertical Transmission
A
ZIKA VIRUS
14
Q
● Blood Transfusion
A
ZIKA VIRUS
JAPANESE AND ST. LOUIS ENCEPHALITIS VIRUS
15
Q
MOT
● Birds
● Mosquito
A
WEST NILE VIRUS
16
Q
Bite of infected Culex species mosquitoes; Vector Mosquito
A
JAPANESE AND ST. LOUIS ENCEPHALITIS VIRUS
17
Q
Nucleic acid amplification test
A
Dengue Fever Viru
18
Q
Serologic tests
A
Dengue Fever Viru
WEST NILE VIRUS
19
Q
RT-PCR
A
ZIKA VIRUS
20
Q
Enzyme-linked immunosorbent assay (ELISA) test
A
DF
JAPANESE AND ST. LOUIS ENCEPHALITIS VIRUS
HEP C
21
Q
Polymerase chain reaction (PCR)
A
JAPANESE AND ST. LOUIS ENCEPHALITIS VIRUS
22
Q
Vaccine
A
Flavi
Arbo
Yellow Fever Virus
23
Q
Use insect repellent
A
Dengue Fever Virus
ZIKA VIRUS
24
Q
● Wear loose-fitting long sleeved shirts and long pants
A
Dengue Fever Viru
25
● Control mosquitoes inside and outside your home
Dengue Fever Viru
26
Vector control
ZIKA VIRUS
27
● Avoid unprotected sex
ZIKA VIRUS
28
● Use insect repellent
Dengue Fever Virus
ZIKA VIRUS
29
No vaccine (SLE)
JAPANESE AND ST. LOUIS ENCEPHALITIS VIRUS
30
Inactivated Vero cell culture
31
derived Japanese encephalitis vaccine manufactured by IXIARO (Japanese Encephalitis)
Inactivated Vero cell culture
32
only JE vaccine licensed and available in the United States
Inactivated Vero cell culture
33
Inactivated Vero cell culture
● it was approved in March 2009 for use in people aged
17 years and older
34
Inactivated Vero cell culture
● May 2013 : it was approved for use in children (?)
2 months through 16 years of age
35
● Fever headache, Muscle aches, Nausea, Red eyes, face, tongue, Yellow skin and eyes.
Yellow Fever Virus
36
● Fever, severe headache, nausea, pain behind the eyes muscle and joint pains.
Dengue Fever Viru
37
● Incubation: 4–10 days after infection; last for 2–7 days
Dengue Fever Virus
38
Asymptomatic
ZIKA VIRUS
39
● Incubation: 2-14 day
ZIKA VIRUS
WEST NILE VIRUS
40
● Symptoms occur in 20%-40% of infected people
WEST NILE VIRUS
41
● Incubation: 2-14 day
ZIKA VIRUS
WEST NILE VIRUS
42
● blood-brain barrier: lymphocytic meningitis
JAPANESE AND ST. LOUIS ENCEPHALITIS VIRUS
43
● fever, headache, nausea, vomiting, diarrhea, and myalgias
JAPANESE AND ST. LOUIS ENCEPHALITIS VIRUS
44
● altered mental status, agitation, confusion, and coma.
JAPANESE AND ST. LOUIS ENCEPHALITIS VIRUS
45
● Incubation: 5 to 15 days
JAPANESE AND ST. LOUIS ENCEPHALITIS VIRUS
46
● Blood transfusion, intravenous drug abuse, hemodialysis, sexual contact with infected partners, acupuncture, tattooing, and sharing of razors
47
Screening Antibody Test HCV
anti-HCV EIA, and RTPCR
48
is used to quantify virus in the blood to monitor antiviral therapy.
RT-PCR and quantitative bDNA (branched chain DNA)
49
used to detect acute hepatitis C infection
ELISA
50
used to determine chronic hepatitis C disease
PCR
51
are used to differentiate patients who are likely to respond to therapy from those with lower response rates.
Highly Sensitive Molecular Biopsy
52
is used to identify genotypes more or less likely to respond to therapy
HCV Genotyping
53
Enveloped virus with a single-stranded RNA genome
Vesicular Stomatitis Virus
54
● Bullet shaped or Rod shaped
Vesicular Stomatitis Virus
55
● Size: 180 x 75 nm
Vesicular Stomatitis Virus
56
● Vector: Insect (Mosquito, Sand fly, Black fly)
Vesicular Stomatitis Virus
57
● Host: Cattle, Horse, Pig, Deer, Human
Vesicular Stomatitis Virus
58
● Bite by rabid dog or other animals
Rabies Virus
59
● Virus ,multiply in the muscle connective tissue, nerves after 48-72 hours
Rabies Virus
60
● If untreated % will developed rabies
50
61
● Virus are carried in saliva virus deposited in the wound site
Rabies Virus
62
● Animals: Insect bite
Vesicular Stomatitis Virus
63
● Humans: Exposure to infected animal
Vesicular Stomatitis Virus
64
● Direct immunofluorescence and Confirmation in the animal
Rabies Virus
65
● PCR
JAPANESE AND ST. LOUIS ENCEPHALITIS VIRUS
Hep C Virus
Vesicular Stomatitis Virus
66
● Rigorous cleansing of the bite wound, Vaccine for dogs and cat, HDCV for humans
Rabies Virus
67
● Vector control, Good sanitation, PPE
Vesicular Stomatitis Virus
68
● Headache, fever,sore throat,
Rabies Virus
69
● Hallucinations
Rabies Virus
70
● Pain or tingling at the site of the bite
Rabies Virus
71
● Afraid of water - hydrophobia
Rabies Virus
72
● Respiratory arrest, death in 1-6 days
Rabies Virus
73
● Seizures
Rabies Virus
74
● Difficulty in drinking
Rabies Virus
75
Vesicular Stomatitis Virus
● Animals: on the feet, mouth, teats, and hooves
Blister-like lesions
76
Vesicular Stomatitis Virus
● Humans: (?) symptoms
Influenza-like
77
Detection of specific antibodies against rabies virus
Rabies Virus
78
● Detection of antibodies against VSV
Vesicular Stomatitis Virus
79
● 60-65 nm
Eastern,Western andEquineEncephalitis Virus
80
● It has a single stranded, positive-sense RNA genome
Eastern,Western andEquineEncephalitis Virus
81
● (German measles) is a generally mild, selflimited illness
Rubella Virus
82
● A single member of the genus Rubivirus in the family Togaviridae.
Rubella Virus
83
● Is a spherical, 40- to 80-nm, positive-sense, singlestranded RNA virus with spike-like
Rubella Virus
84
● 60-70nm
Chikungunya
85
● Spherical
Chikungunya
86
● Positive-sense, single strand RNA genome surrounded by a lipid envelope
Chikungunya
87
Virus enters the bloodstream via the saliva of an infected female mosquito
Eastern,Western andEquineEncephalitis Virus
88
● Direct contact with the person who has rubella
Rubella Virus
89
● Droplet contact with respiratory secretions
Rubella Virus
90
● Possible transplacental infection of fetus during viremia
Rubella Virus
91
virus infection begins when an infected mosquito bites a human and the virus is introduced into the skin and bloodstream.
Chikungunya
92
The virus replicates in the fibroblasts of the dermis and disseminates through the bloodstream to several tissues.
Chikungunya
93
Viral replication occurs in target tissues — mainly muscles, joints, and skin, as well as the liver, spleen, and meninges in neonates and patients with underlying conditions.
Chikungunya
94
Inflammatory cells are recruited to infected tissues.
Chikungunya
95
Joints (including in the fingers, wrists, elbows, knees, ankles, and toes) become inflamed in response to viral replication and inflammatory infiltrates.
Chikungunya
96
● Serology and viral identification by PCR on a cerebrospinal fluid obtained after a lumbar puncture
Eastern,Western andEquineEncephalitis Virus
97
● Blood tests
Rubella Virus
98
● Nasal or throat swabs.
Rubella Virus
99
● Urine tests
Rubella Virus
100
● It may be detected directly in blood samples collected using test such as reverse transcriptase-polymerase chain reaction ( RT-PCR)
Chikungunya
101
● There is no vaccine available
Eastern,Western andEquineEncephalitis Virus
102
● Routine childhood immunization
Rubella Virus
103
● Immunization of susceptible adolescent
Rubella Virus
104
● Valneva vaccine
Chikungunya
105
● Fever
Eastern,Western andEquineEncephalitis Virus
106
● Severe depression ―sleeping sickness‖
Eastern,Western andEquineEncephalitis Virus
107
● Behavior changes
Eastern,Western andEquineEncephalitis Virus
108
● Impaired vision
Eastern,Western andEquineEncephalitis Virus
109
● Circling or head pressing
Eastern,Western andEquineEncephalitis Virus
110
● Muscle twitches
Eastern,Western andEquineEncephalitis Virus
111
● Inability to swallow
Eastern,Western andEquineEncephalitis Virus
112
● Paralysis
Eastern,Western andEquineEncephalitis Virus
113
● Convulsions, Death
Eastern,Western andEquineEncephalitis Virus
114
● Mild fever of 102 F (38.9 C) or lower
Rubella Virus
115
● Headache
Rubella Virus
116
● Stuffy or runny nose
Rubella Virus
117
● Red, itchy eyes
Rubella Virus
118
● Enlarged, tender lymph nodes
Rubella Virus
119
● A fine, pink rash that begins on the face
Rubella Virus
120
● Aching joints
Rubella Virus
121
● High fever
Chikungunya
122
● Rigors
Chikungunya
123
● Headache
Chikungunya
124
● Photophobia
Chikungunya
125
● Petechial rash or maculopapular rash
Chikungunya
126
● IgG Avidity Testing
Rubella Virus
127
● Specific igM antibodies usually usually appear upon cessation of viremia, usually by day 5-7 into the illness and stay positive for 3 to 6 months
Chikungunya
