Rest Flashcards by Anne Engbers | Brainscape

Q

Olaparib

A

Inhibits PARP1 > double strand break >when tumors don’t have HR > apoptosis
Only ovarian cancer

How well did you know this?

1

Not at all

2

3

4

5

Perfectly

Q

POLE/MMR deficient tumors

A

Better prognosis

Lots of T-cell infiltration

How well did you know this?

1

Not at all

2

3

4

5

Perfectly

Q

MMR proficient tumors

A

Worse prognosis

How well did you know this?

1

Not at all

2

3

4

5

Perfectly

Q

MSI

A

Caused by MMR deficiency

Associated with colon and gastric cancer

How well did you know this?

1

Not at all

2

3

4

5

Perfectly

Q

EMT

A

Loss of E-cadherin

Gain of N-cadherin

How well did you know this?

1

Not at all

2

3

4

5

Perfectly

Q

CHEK2 mutation

A

BRC

1100delC

How well did you know this?

1

Not at all

2

3

4

5

Perfectly

Q

NTHL1 mutation

A

ademenatous polyposis, CRC

How well did you know this?

1

Not at all

2

3

4

5

Perfectly

Q

HIF-1alpha

A

Oxgen sensing, stimulation of angiogenesis

How well did you know this?

1

Not at all

2

3

4

5

Perfectly

Q

KRAS mutational tumors

A

Not sensitive to EGF-inhibitors

How well did you know this?

1

Not at all

2

3

4

5

Perfectly

Q

5-FU

A

MMR proficient tumors

How well did you know this?

1

Not at all

2

3

4

5

Perfectly

Q

PD1

A

Expressed by activated T-cells

When bound to PDL1 inhibits T cell activity

How well did you know this?

1

Not at all

2

3

4

5

Perfectly

Q

Anti-PD1 therapy

A

Best for tumors with lots of mutations

How well did you know this?

1

Not at all

2

3

4

5

Perfectly

Q

Double minutes

A

Small fragments of extrachromosomal DNA

Chromothripsis>gene amplification>double minutes

How well did you know this?

1

Not at all

2

3

4

5

Perfectly

Q

Chromothripsis

A

Thousands of chromosomal rearrangements

How well did you know this?

1

Not at all

2

3

4

5

Perfectly