Hemostasis Flashcards by Anne Engbers

Q

GpVI

A

Can directly bind collagen

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Q

GpIa

A

Can directly bind collagen

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Q

GpIb

A

Can indirectly bind collagen through vWF

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Q

GpIIb/IIIa

A

Presented on activated platelets

Binds other platelets through fibrinogen and vWF

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Q

Alpha granule

A

Fibrinogen and vWF

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Q

Dens granule

A

Serotonin, ADP, Ca2+

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Q

Serotonin

A

Vasoconstriction

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Q

ADP

A

Platelet activation and aggregation

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Q

TXA2

A

Vasoconstriction and platelet activation

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Q

Intrinsic pathway activated by

A

Exposure of subendothelial collagen

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Q

Extrisnsic pathway activated by

A

TF produced by endothelial cells

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Q

Factors in intrinsic pathway

A

XII > XI > IX+VIII > XV > II > I

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Q

Factors in extrinsic pathway

A

TF+VII > X + V > II > I

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Q

IIa

A

Cleaves fibrinogen
Activates factor XIII
Activates factor VIII

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Q

hMWK

A

Cofactor for XII

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Q

HMWK

A

Cofactor for XI

Q

VIII

A

Cofactor for IX

Q

XIII

A

Forms crosslinks between the D-domains of fibrin