Genes

Question 1

TP53

Answer 1

Apoptosis or senescence

Mutated in >50% of all tumors

Question 2

BCR/ABL

Answer 2

Philadelphia chromosome
Constantly activated kinases
>95% of CML patients

Question 3

MYC/IGH

Answer 3

B-cell expansion and cell proliferation

EBV infections

Question 4

APC

Answer 4

Degenerates B-catenin

Mutated in CRC

Question 5

MLH1

Answer 5

MMR
Lynch, CRC
High risk of development at young age

Question 6

MSH2

Answer 6

MMR
Lynch, CRC
High risk of development at young age

Question 7

MSH6

Answer 7

MMR

Lynch, CRC

Question 8

PMS2

Answer 8

Lynch, CRC

Older age of development

Question 9

NTHL-1

Answer 9

Helps in BER

Adenomatous polyposis, CRC

Question 10

BRAC1

Answer 10

HR
Mutations in 3% of all BRC
Mutations in 8% of ovarian cancers

Question 11

BRAC2

Answer 11

HR
Mutations in 2% of all BRC
Mutations in 6% of ovarian cancers

Question 12

CHEK2

Answer 12

TSG

Mutated in BRC

Question 13

CDKN2A

Answer 13

Encodes for p14 & p16 TSG’s
40% of melanomas
p16 mutated –> pancreatic cancer

Question 14

BRAF

Answer 14

Oncogene
Mutated in 8% of all cancers
Accounts for 52% of mutations in melanomas

Question 15

EGFR

Answer 15

PI3K activation

Mutated in lung cancer