Hematopoiesis

Question 1

Lifespan granulocytes

Answer 1

1-2 days

Question 2

Lifespan lymphocytes

Answer 2

days to years

Question 3

Lifespan monocytes

Answer 3

12 hours

Question 4

Neutrophils

Answer 4

Defense against encapsulated bacteria

Increase in number during infection

Question 5

Eosinophils

Answer 5

Mediate allergic responses

Red granules

Question 6

Basophils

Answer 6

Mediate allergic responses

Blue-purple granules

Question 7

Monocytes

Answer 7

Phagocytosis of bacteria

Secretion of TNF, IL-1

Question 8

Embryonic development

Answer 8

Islands in yolk sac > liver and 20% speel > bone marrow

Question 9

Innate immunity

Answer 9

First 12 hours

Phagocytes, dendritic cells, complement factors, NK cells

Question 10

Adaptive immunity

Answer 10

First few days

B and T lymphocytes, plasma cells, antibodies

Question 11

EPO

Answer 11

Production in kidneys

Increases anti-apoptotic BCLXL and reduces level of cell-cycle inhibitors

Question 12

G-CSF

Answer 12

Production in endothelial cells, fibroblasts and microphages
Stimulates granulocyte production
Causes leukocytosis in patients with infection
Indications are granulocytopenia and stem cell mobilization

Question 13

TPO

Answer 13

Production in liver
Stimulates platelet production and supports survival and proliferation of HSC’s
For Immune thrombocytopenia

Question 14

SDF-1

Answer 14

Homecoming factor

Question 15

CXRCR4

Answer 15

HSC’s receptor for SDF-1