Hemostasis 2 Flashcards
1
Q
TFPI
A
Inhibits Xa
Forms TFPI-Xa complex
2
Q
TFPI-Xa complex
A
Inhibits TF-VII
3
Q
ATII
A
Inhibits IIa, IXa, Xa, XIa
4
Q
Heparin
A
Increases ATII activity
5
Q
Thrombumodulin
A
When bound to IIa, activates protein C
6
Q
Protein C
A
With protein S inhibit cofactors Va and VIIIa
7
Q
Vitamin K
A
Cofactor for enzyme gamma-glutamyl carboxylase
8
Q
Without vitamin K no synthesis of
A
II, VIII, IX, X, PC, PS
9
Q
Factor V Leiden
A
SNP in exon 10
Prolonged half-life of factor V > more thrombin formation
Thrombosis risk 3-16%
Homozygosity doesn’t mean you’ll get thrombosis
10
Q
aPTT
A
Intrinsic pathway
Measures shortage of I, II, VIII, IX, XI, XII
11
Q
PT
A
Extrinsic pathway
Measures shortage of I, II, V, VII
