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MOD2 > Fibrinolysis > Flashcards

Fibrinolysis Flashcards

1
Q

tPA dependent plasmin generation

A

tPA produced by endothelial cells + cofactor Ia > Plasminogen to plasmin

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2
Q

uPA dependent plasmin generation

A

Produced by endothelial & epithelial cells, macrophages

sc-UPA + plasmin > tc-UPA > plasminogen to plasmin

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3
Q

Plasmin

A

Cleaves between the E- and D-domans of fibrin

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4
Q

PAI-1

A

Produced by endothelium, platelets, monocytes

tPA & uPA inhibitor

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5
Q

Alpha2AP

A

Produced by liver

Fast and efficient inhibition of plasmin

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6
Q

TAFI

A

TAFI + IIa > TAFIa

Removes lysins from fibrinsurface > tPA and plasminogen cannot bind

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MOD2 (23 decks)

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