Pharmacotherapy 1 Flashcards

1
Q

Cytostatics

A

Alkylating agents
Antimetabolites
Antimitotics
Topoisomerase inhibitors

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2
Q

Alkylating agents working and medicine

A

Inhibition of DNA replication
Cisplatin
Carboplatin
Cyclophosphamide

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3
Q

Cisplatin

A

Alkylating agent

Testis, bladder, ovary, cervix and lung

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4
Q

Carboplatin

A

Alkylating agent
Ovary carcinoma
In CRC in combination with 5-FU

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5
Q

Cyclophosphamide

A

Alkylating agent

Leukemia, prostate, breast

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6
Q

Antimetabolities working and medicine

A

During S-phase
Methotrexate
5-FU
Gemcitabine

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7
Q

Methotrexate

A

Antimetabolite

Breast, placenta, bladder, leukemia

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8
Q

5-FU

A

Antimetabolite

Colon, stomach, breast, prostate, epithelial carcinoma of head and neck

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9
Q

Gemcitabine

A

Antimetabolite

Carcinomas

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10
Q

Antimitotics working and medicine

A

Inhibit microtuble formation
Vinblastine
Vincristine
Vinorelbine

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11
Q

Vinblastine

A

Antimitotic

Lymphomas, germ cell and carcinomas

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12
Q

Vincristine

A

Antimitotic

Lymphomas, leukemias, pediatric tumors

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13
Q

Vinorelbine

A

Antimitotic

Metastasized BRC when other therapies failed

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14
Q

Topoisomerase inhibitors working and medicine

A

Prevent DNA repair and induce DNA damage
Topotecan
Etoposide
Doxorubicin

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15
Q

Etoposide

A

Topoisomerase inhibitor

Testis, bronchus carcinoma, leukemias

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16
Q

Topotecan

A

Topoisomerase inhibitor

Ovary carcinoma, CRC

17
Q

Doxorubicin

A

Non-Hodgkin, Hodgkin, acute leukemias, sarcomas

18
Q

Adverse effects of cytostatics

A
Nausea
VOmiting
Myelosuppression
Alopecia
Damage to mucosal epithelium