Response to traumatic brain injury Flashcards

1
Q

Subarachnoid hemorrhage causes damage by:

A
  • Raising ICP
  • Direct pressure on tissue
  • Depriving downstream tissue of blood
  • Vasospams - ischemic injury
  • Inflammation of meningies - increase CSF in ventricles - hydrocephalus
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2
Q

Hydrochepahlus =

A

Dilated ventricles due to CSF

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3
Q

Classic symptoms of subarachnoid

A
  • Nucal stiffness
  • Thunderclap headache
  • Raised ICP symptoms
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4
Q

Symptoms of subdural can be

A

Delayed in onset

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5
Q

Symptoms of subdural:

A

Loss of consciousness
Vomiting
Focal lesion
Headache

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6
Q

Subdural hematoma can lead to what in the brain

A

Midline shift

Herniation

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7
Q

Concussion is a

A

diffuse brain injury

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8
Q

Chronic concussions can cause a build up of

A

Tau proteins in neurones

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9
Q

2 types of injury in concussion

A

Couo-coutercoup

Torque

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10
Q

Troque injuries can effect

A

Reticular activating system

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11
Q

What can cause rapid cerebral oedema after concussion

A

Secondary impact syndrome

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12
Q

Symptoms of concussion

A

Memory loss
Confusion
LOC

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13
Q

Hematoma =

A

A collection or clotting of blood outside the vessel.

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14
Q

Types of altered conscious level in response to injury:

A
  • Loss of consciousness
  • Post-traumatic amnesia
  • Pre-traumatic amnesia
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15
Q

Why should you always ask about memory and LOC around time of trauma?

A

PTA is an important risk factor for a brain bleed

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16
Q

Primary brain injury =

A

Occurs during initial insult, mechanical damage

17
Q

Primary brain injuries can be what?

A

Focal or diffuse

18
Q

What can cause progressive brain damage?

A
Mechanoporation
Calcium flux
O2 free radicals
Cytokine
Axotomy
19
Q

Axotomy =

A

severing an axon

20
Q

Secondary injury =

A

Not caused by mechanical damage. Results from the process initiated by trauma.

21
Q

Ex of things that can happen AFTER inital injury

A

Seizures

Infection

22
Q

Ex of secondary injuries

A
Raised ICP
Hypoxic brain injury
Ischemic brain injury
Seizures 
Infection
23
Q

ICP =

A

Brain matter + CSF + Blood

24
Q

Cerebral blood flow is under what?

A

Autoregulation

25
Autoregulation acts to
Maintain cerebral blood flow at all times. Vasodilartion and vasoconstriction
26
Monroe-Kelly doctrine =
Decribes relationship between ICP, blood, brain and CSF. Decribes uncompensated state that is reached when mass reaches a certain size
27
Initially, what happens when ICP increases
CSF less produced, more absorbed | Vasoconstriction
28
Normal ICP =
10 mmHG
29
Abnormal ICP
>20 mmHg
30
Severe ICP
> 40 mmHg
31
Mass effect =
phenomenon in which a focal lesion causes surrounding areas of brain tissue or brain structures to be compressed and injured due to the degree of space that leaking blood, cerebrospinal fluid, or edema takes up within the restricted skull space.
32
CPP stands for
Cerebral perfusion pressure
33
CPP =
MBP - ICP
34
What compensated for increased ICP to maintain CPP
Cushing response
35
Cushing reflex =
Increase BP to maintain CPP in response to ICP
36
Head injury will do what to BP?
Increase
37
To save the brain ...
Save the heart