respiratory system Flashcards
functions of respiratory system
gas exchange, communication, olfaction, acid base balance, blood pressure regulation, blood and lymph flow, platelet production, blood filtration
principal organs
nose, pharynx, larynx, trachea, bronchi, lungs
facial part is shaped by bone and hyaline cartilage
nose
muscular funnel extending about 5 in. from choanae to larynx
pharynx (throat)
cartilaginous chamber about 4 cm (l.5 in.) long
larynx (voice box)
keeps food and drink out of airway
larynx
rigid tube, anterior to esophagus, 16 to 20 C-shaped rings of hyaline cartilage
trachea
lined by ciliated pseudostratified columnar epithelium
trachea
crowded by adjacent organs, does fill entire ribcage, not symmetrical
lungs
arise from fork of trachea, supported by C-shaped hyaline cartilage rings
main bronchi
trace the flow of air from the nose to the pulmonary alveoli
nose-nasal cavity-pharynx-larynx-trachea- carina-primary bronchus-secondary bronchus-terminal bronchus- respiratory bronchioles -alveoli
highly organized hyaline cartilage, incomplete rings to allow esophagus to expand when eating
trachea
muscles in forced expiration
rectus abdominis, internal intercostals, abdominal, and pelvic muscles
greatly increased abdominal pressure pushes viscera up against diaphragm increasing thoracic pressure, forcing air out; important for “abdominal breathing”
forced expiration
energy saving passive process achieved by the elasticity of the lungs and thoracic cage
normal quiet respiration
as muscles relax, structures recoil to original shape and original (smaller) size of thoracic cavity
normal quiet respiration
inspiration:
inhaling
expiration:
exhaling
prime mover of repiration
diaphragm (contracts to flat shape)
breathing is controlled at what two levels of the brain
cerebral and conscious; unconscious and automatic
automatic, unconscious breathing is controlled by respiratory centers in the reticular formation
medulla oblongata and pons
primary generator of the respiratory rhythm, produces a respiratory rhythm of 12 breaths per minute
ventral respiratory group (VRG)
in quiet breathing (eupnea), inspiratory neurons fire for about 2 seconds, expiratory neurons fire for 3 seconds
ventral respiratory group
modifies the rate and depth of breathing, receives influences from external sources
dorsal respiratory group (DRG)
one pair of respiratory center in the pons
Pontine respiratory group (PRG)
modifies rhythm of VRG by outputs to both VRG and DRG
pontine respiratory group
adapts breathing to special circumstances such as sleep, exercise, vocalization, and emotional responses
pontine respiratory group
describes air flow in and out of lungs during ventilation
boyle’s law
changing volume creates a ___
pressure gradient
F is related to the change in ___
pressure over resistance
____ pressure falls with more volume and rises with less volume
inter pulmonary
slightly negative pressure that exists between the two pleural layers
intrapleural pressure
volume of gas is directly proportional to its absolute temperature, affects expansion of lungs
charles law
two factors influence airway resistance:
bronchiole diameter and pulmonary compliance
increases airflow, epinephrine and sympathetic stimulation
diameter of the bronchioles
decreases airflow, suffocation can occur, histamine, parasympathetic nerves, cold air, and chemical irritants
bronchoconstriction
ease with lungs can expand, reduced by degenerative lung diseases, limited by surface tension of water film inside alveoli
pulmonary compliance
conduction zone of airway where there is no gas exchange, can be altered somewhat by sympathetic dilation
anatomic dead space
space that is filled with air that cannot exchange with the blood
anatomic dead space
important to deduct this amount when calculating alveolar ventilation rate
anatomic dead space
volume of air inhaled and exhaled in one cycle of breathing (500mL)
tidal volume
max inward breath
inspiratory reserve volume
max outward breath
expiratory reserve volume
air still remaining in lungs after maximum expiration (cannot be expelled)
residual volume
air that can be inhaled or exhaled with maximum effort
vital capacity
air breathed in normally (normal tidal expiration)
inspiratory capacity
maximum air lungs can contain
total lung capacity
air remaining after normal breath
functional residual capacity
relaxed, quiet breathing
eupnea
temporary cessation of breathing (one or more skipped breaths)
apnea
labored, gasping breathing;shortness of breath
dyspnea
increased rate and depth of breathing in response to exercise, pain, or other conditions
hyperpnea
increased pulmonary ventilation in excess of metabolic demand, frequently associated with anxiety
hyperventilation
reduced pulmonary ventilation leading to an increase in blood CO2
hypoventilation
deep, rapid breathing often included by acidosis
kussmaul respiration
dyspnea that occurs when person is lying down
orthopnea
permanent cessation of breathing
respiratory arrest
accelerated respiration
tachypnea
the separate contribution of each gas mixture
partial pressure
alveolar air mixes with
residual air
air is humidified by contact with
mucous membranes
___ exchanges O2 and CO2 with blood
alveolar air
inspired air mixes with air left from the previous
respiratory cycle
gases diffuse down their own gradients until the ___ of each gas in the air is __ to its partial pressure in water
partial pressure; equal
at the air- water interface, for a given temperature, the amount of gas that dissolves in the water is determined by its solubility and its partial pressure in air
henrys law
the greater the PO2 in the ___, the more O2 the blood picks up
alveolar air
behaves independently, one __ does not influence the diffusion of another
gas
for __ to get into the blood, it muust dissolve in this water and pass through the respiratory membrane separating the air from the bloodstream
oxygen
must pass the other way and then diffuse out of the water film into the alveolar air
for carbon dioxide to leave blood
less gradient, less __ diffuses into blood. more gradient, more __ diffuses into blood
oxygen
process of carrying gases from the alveoli to the systemic tissues and vice versa
gas transport
oxygen in
98.5% bound to hemoglobin and 1.5% dissolved in plasma
90% is hydrated to form carbonic acid, 5% is bound to proteins, and 5% is dissolved as a gas in plasma
carbon dioxide transport
70% of CO2 comes form carbonic acid, 23% comes from proteins, and 7%comes straight from plasma
carbon dioxide exchange
specialized for oxygen transport, has 4 protein (globin) portions
hemoglobin
O2 bound to hemoglobin
oxyhemoglobin
hemoglobin with no O2
deoxyhemoglobin
1 can carry up 4 O2, each has a heme group, binds one O2 to an iron atom
hemoglobin
carbon dioxide is transported in 3 forms:
gas dissolved in plasma, carbonic acid dissolved in plasma, carbamino compounds
4 factors adjust rate of oxygen unloading to match need:
ambient PO2, temperature, ambient pH, bisphosphoglycerate (BPG)
O2 is released from Hb, active tissue has (down arrow) PO2
ambient PO2
active tissue has (up arrow) CO2, lower pH of blood, promotes O2 unloading
ambient pH (bohr effect)
RBCs produce this, which binds to Hb; O2 in unloaded
bisphosphoglycerate (BPG)
body temp (fever), thyroxine, growth hormone,
testosterone, and epinephrine all raise BPG and promote
O2 unloading
bisphosphoglycerate (BPG)
active tissues has this, promotes O2 unloading
temperature
__ unloads O2 to match metabolic needs of different states of activity of the tissues
hemoglobin
rate of __ loading also adjusted to meet needs
CO2
rate and depth of breathing adjust to maintin
arterial blood levels
pH =
7.35 to 7.45
PCO2
40mmHg
PO2
95mm Hg
brainstem respiratory centers receive input from central and ___ that monitor composition of CSF and blood
peripheral chemoreceptors
most ___ for breathing is pH, followed by CO2, and least significant is O2
potent stimulus
deficiency of oxygen or the inability to use oxygen, a consequence of respiratory disease
hypoxia
state of low arterial PO2, usually due to inadequate pulmonary gas exchange
hypoxemic hypoxia
inadequate circulation of blood (congestive heart failure)
ischemic hypoxia
due to inability of the blood to carry adequate oxygen
anemic hypoxia
metabolic poisons (cyanide) prevents O2 use in tissue
histotoxic hypoxia
blueness of the skin, (sign of hypoxia)
cyanosis