Respiration Flashcards
What are the components of the upper respiratory tract?
Nose, pharynx and larynx
What are the components of the lower respiratory tract?
Trachea, bronchus, lungs
What are the 3 parts of the pharynx
Nasopharynx, oropharynx, laryngopharynx
What components of the pharynx are exposed to both air and food?
Oropharynx and laryngopharynx
What part of the pharynx is only exposed to air?
Nasopharynx
What is the surface area of the lungs, and what is it comparable to?
100m2, half the size of a tennis court
What system is the pharynx apart of?
Digestive & respiratory
What travels down the pharynx?
Air and food
What closes the nasopharynx when swallowing?
Soft palate
What 2 things are essential for efficient gas exchange?
Small diffusion distance between air and blood
Large surface area
Approximately how many breaths are taken at rest per min?
~10/min
What is the diffusion distance between the air in the lungs and blood?
0.5 micrometers (1/15th of a RBC)
Approximately how many litres of air does 1 breath contain?
1/2 a litre
What is respiration?
Exchange of gases
What is ventilation?
The mechanical movement of air in and out (breathing)
What are the 3 types of respiration?
External, internal and cellular
What is external respiration?
Exchange of gasses in the lungs across pulmonary capillaries
What does the ventilatory pump include?
The diaphragm, rib cage and associated muscles
What is internal respiration?
Exchange of gasses between blood in systemic capillaries and systemic tissues
What is cellular respiration?
The process by which individual cells gain energy
What is the primary role of the conducting part of the respiratory system?
Conduct air and prepare it for exchange by warming, cleaning, and humidifying it
What is the primary role of the respiratory part of the respiratory system?
Gas exchange
What are the 2 functional parts of the respiratory system?
Conducting and respiratory
What are the conducting airways?
Nasal cavities, pharynx, larynx, trachea, bronchi and bronchioles
What are the respiratory airways in the respiratory part of the system?
Respiratory bronchioles, alveolar ducts and sacs, and the alveoli themselves
What is the process by which cilia clear the conducting airways?
Mucociliary clearance
How often do cilia beat?
10-15 times per second
What are the 3 requirements for air in order for gas exchange?
Clean, warm (37 degrees), saturated with water
In which direction do cilia beat?
Towards the throat
How is blood warmed in the nasal cavity?
The very rich blood supply under the epithelium
What are the 3 bones in the nasal cavity called, and what do they form?
Turbinate bone forms conchae (superior, middle and inferior)
What is the purpose of the Choncae?
Increase surface area (to maximise warming and humidifying)
Swirl air around to create turbulence, throwing particles onto mucous layers
Describe the lining of the conducting airways
Pseudostratified ciliated columnar epithelium, goblet cells, basal cells
What do paranasal sinuses do?
Lighten face and add resonance to voice
What is the temperature of the air by the time it reaches the throat?
~32 degrees
What part of the respiratory system slows air down?
Nasal cavity
What do seromucous glands secrete and why?
Secrete a watery product to help humidify and filter air
What do goblet cells secrete and why?
Secrete a mucin to help humidify and filter air
Why is an infection in the lower respiratory tract more dangerous than the upper respiratory tract?
Because it is closer to the blood supply
What are the 2 sources of mucous in the respiratory tract?
Mucous glands and Goblet cells
What are nose hairs also known as?
Vibrissae
What are the overall 3 main functions of the nose?
- Warm, moisten and filter air
- Detect olfactory stimuli
- Modify speech vibrations
What is the name of the bone where the olfactory receptor cells are located?
Cribriform plate
Name the order of the branches in the respiratory tree
Trachea -> main stem bronchi -> lobar bronchi -> segmental bronchi -> smaller bronchi -> bronchioles -> terminal bronchioles -> respiratory bronchioles -> alveolar ducts -> alveolar sacs
How many generations of branching are there in the airways?
28
What angle do branches branch off at?
37 degrees
What is the main purpose of the branching in the respiratory tract?
Increase surface area
How long and wide is the trachea?
12cm long, about as wide as a thumb
What 2 things decrease as you go further down the respiratory tract?
Tube diameter and epithelial height
What is the shape of the cartilage in the trachea?
C shaped ring
What does the cartilage in the trachea do?
Protect the trachea and keep it open
What is the widest tube in the respiratory tract?
Trachea
What is the name of the muscle connecting the ends of the incomplete cartilage rings in the trachea?
Trachealis muscle
What is the role of the trachealis muscle?
Narrow diameter of the trachea - possibly involved with cough reflex if food enters trachea
What are the 4 layers of the bronchus?
Respiratory epithelium -> smooth muscle -> mucous & serous glands -> cartilage
What is between the cartilage rings in the trachea?
Connective tissue - allows for flexibility
What is the shape of cartilage in the bronchus?
Crescent moon-shaped (not as big as C)
What cells do bronchiole have instead of goblet cells?
Club cells
What do club cells do?
Secrete watery substance to prevent walls from sticking together during expiration
Secrete chemicals to break down bacteria
Describe the walls of bronchioles
simple columnar or cuboidal epithelia with club cells on top of smooth muscle
Where is the site of major broncho-constriction?
Bronchioles
What is the difference between terminal and respiratory bronchioles?
Respiratory bronchioles have alveoli buds
What is the final branch of the conducting zone?
Terminal bronchioles
What is the first branch of the respiratory zone?
Respiratory bronchioles
What generation of branching forms bronchioles?
16th
What is the final branch of the respiratory zone?
Alveolar sacs
What is an alveolar sac?
More than 2 alveoli in an area
What are the 2 types of alveolar cells?
Type 1: Pneumocytes
Type 2: Surfactant cells
Describe type 1 alveolar cells
Squamous epithelium
What is the purpose of type 2 alveolar cells?
Reduce surface tension, preventing alveolar collapse
What is the 3rd type of alveolar cell, and what does it do?
Alveolar macrophage - picks up and destroys debris that the conducting system has failed to filter
What is the final line of immune defence in the lungs?
Alveolar macrophage
Describe the order in which oxygen must pass through to get from the lungs to the blood
Lumen of alveolus -> type 1 pneumocyte cytoplasm -> fused basement membrane of Type I alveolar cell and endothelial cell -> cytoplasm of capillary endothelium -> blood plasma -> RBC
How many lobes does the right lung have?
3
How many lobes does the left lung have?
2
What is the name of the region in which arteries, veins and bronchi enter each lung?
Hilum
What is the name of the bronchi supplying each lobe?
Lobar bronchi
What is the name of the bronchi supplying each lung?
Main stem bronchi
What is the name of the bronchi supplying each segment?
Segmental bronchi
How many segments are in the left lung?
8
How many segments are in the right lung?
10
What are the 3 factors affecting pulmonary ventilation?
Surface tension, lung compliance, airway resistance
Is expiration active or passive?
Passive
Is inspiration active or passive?
Active
What percentage of air movement into and out of the lungs is the ribcage responsible for?
25%
What muscles are involved with inspiration and what do they do?
External intercostal muscles - contract during inspiration to lift ribs upwards
What muscles are involved with expiration and what do they do?
Internal intercostal muscles - usually not contracting - only contract during forceful exhalation to drag ribs downwards
What is the relationship between volume and pressure?
Volume is inversely proportional to pressure (e.g. as volume increases pressure decrease)
What does contraction of the diaphragmatic muscle do, and when does this occur?
Flatten the diaphragm, pulling it down - increasing the volume of the thorax during inspiration
What percentage of the bulk flow of air is the diaphragm responsible for during quiet breathing?
75% (this decreases during exercise)
What is VT?
Tidal volume - the volume of air per breath at rest ~0.5L
What is FRC?
Functional residual capacity - the amount of air in the lungs after passive expiration (~1.8L - 2.4L)
What is VR?
Residual volume - the volume of air in the lungs that cannot be expelled ~1/2 FRC
What is ERV?
Expiratory Reserve Volume - the extra air exhaled forcefully on top of VT - (FRC-VR)
What is IRV
Inspiratory reserve volume - additional air inhaled on top of VT
What is the calculation for ventilation (L/min)?
VT x Respiratory Frequency
What is FEV1?
Forced expiratory volume - the volume of gas exhaled in 1 sec during forced exhalation
What is FEC?
Maximum expiration after maximum inhalation
How is the visceral pleura attached to the lungs?
Surface tension
When are the forces on the chest wall and forces on the lungs balanced?
At FRC
What is the equation for residual volume?
TLC - VC
What is the approximate dead space in a healthy person?
150ml
What would you expect the pleural pressure to be after a pneumothorax?
0mmHg
Where is total resistance the largest?
Segmental Bronchi