Resp. function tests Flashcards

1
Q

What limitations/ problems may arise when completing respiratory function tests

A
  • Need to understand orders
  • Max effort
  • Mouthpiece leak
  • Ability to carry out orders
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2
Q

What is normal resp rate

A

<25

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3
Q

What is plotted in spirometry

A

Volume/ time

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4
Q

What is the FEV1/ VC if there is an obstructive defect

A

<75%

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5
Q

What is an obstructive defect typical in

A

Asthma, COPD, upper airway obstructions

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6
Q

What is the FEV1/ VC ratio in a restrictive defect

A

> 75%

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7
Q

What is restrictive defect typical in

A

Lung fibrosis, reduced chest wall movement and muscle disease

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8
Q

When is peak flow typically reduced

A

Large airway obstruction
Upper airway obstruction
Asthma

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9
Q

What diseases effect peak flow less

A

COPD

Small airway disease

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10
Q

When is peak flow lowest

A

Morning

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11
Q

What pattern is seen on peak flow charts with asthma

A

Saw tooth pattern

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12
Q

What changes in peak flow must be observed with asthma to determine diagnosis

A
  • > 20% dirunal variation for 3 days a week for 2 weeks
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13
Q

With what kind of training may peak flow increase

A

Inspiratory muscle training

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14
Q

What changes in FEV1 must be seen after use of bronchodilators to determine obsuctive disease is reversible

A

Increase by >15% or 200ml

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15
Q

A 15% increase in FEV1 is adequate to suggest reversibility after….

A

a) 400mg salbutamol via spacer
b) 2.5mg by nebuliser
c) 30mg/day of steroids for 14 days

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16
Q

What may be the problem if there is reduced inspiratory limb flow with normal expiratory flow

A

Extra-thoracic obsutrction

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17
Q

What may be the problem if there is reduction in both inspiratory and expiratory flow

A

Intra-thoracic obsutrction such as a goitre

18
Q

How do you measure vital capacity

A

Spirometry

19
Q

How can you measure total lung capacity

A
  • Inspiration of gas mixture including helium
  • Rebreathing
  • Dilution of helium and decrease in concentration * vital capacity= TLC
20
Q

Where do oxygen and co2 diffuse

A

Oxygen diffuses into circulation

CO2 diffuses out of the lungs

21
Q

How can you calculate alveolar volume and gas transfer

A
  • Single large breath of air with CO and helium

- Calculate total CO transfer and per l of lung volume

22
Q

What does TLCO stand for and how do you calculate it

A

Transfer factor for CO

=kco*va

23
Q

What can cause decreased TLCO (4)

A
  • Anaemia
  • Decreased perfusion
  • Decreased ventilation
  • V/Q mismatch
24
Q

What can cause increased TLCO (3)

A

Increased CO
Polycythaemia
Alveolar haemorrhage

25
Describe the Fick principle
Volume of gas per unit time which diffuses across a tissue sheet is a) proportional to sheet area b) inversely proportional to thickness c) proportional to difference in pressure on either side d) dependent of permeability coefficient for gas
26
What equation can be derived from the Fick principle
= area/thickness * pressure * diffusion constant
27
What does diffusion constant depend upon
Solubility and molecular weight of gas
28
What is Grahams law
Rate of diffusion of a gas is inversely proportional to square root of molecular weight
29
What are the real life causes of reduced surface area causing reduced gas transfer
Pneumonectomy, lobectomy or reduced ventilation from obsutrction Reduced effective area with emphysaemia or increased dead space
30
What are the real life causes of increased membrane thickness
Pulmonary fibrosis Alveolar proteinosis Acute lung injury
31
What are the real life causes of reduced oxygen concentration
High altitude
32
Define airway resistance
Pressure difference between alveolae and the mouth
33
How can airway resistance be measured
Body plethysmograph | Direct measurment of intrathoracic oesophageal pressures
34
What is lung compliance defined as
Volume change per unit of pressure
35
What does lung compliance depend upon
Alveolar surface tension and distensibility of lung tissue
36
When is lung compliance increased/ decreased
Increased: emphysaema Decreased: Lung fibrosis
37
What is the effect of thorax deformities on chest wall compliance
Compliance is reduced
38
Where is perfusion and ventilation highest
At the base
39
How does pneumonia lead to hypoxia
Reduced ventilation | Increased perfusion
40
What does anaerobic threshold correlate with
Cardiopulmonary capacity | Operative risk
41
What is the effect of muscle wasting in COPD
Reduces maximum inspiratory muscles | Problems with mitochondrial dysfunction