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CR 2 > Anaphylactic shock > Flashcards

Anaphylactic shock Flashcards

1
Q

Where do T lymphocytes mature

A

Thymus

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2
Q

Where do B lymphocytes mature

A

Bone marrow

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3
Q

Do T lymphocytes or B lymphocytes use antibodies?

A

Just B

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4
Q

What cells are involved in innate immunity

A
  • Neutrophils
  • Monocytes
  • Eosinophils
  • Mast cells
  • Basophils
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5
Q

Functions of the antibody IgG

A

Blocks pathogen binding
Activates complement
Opsonine antigen for phagocytosis

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6
Q

Functions of the antibody IgM

A

Blocks pathogen binding

Activates complement cascade

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7
Q

Functions of the antibody IgA

A

Blocks pathogen binding

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8
Q

Where is IgA found

A

Tears

Digestive juices

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9
Q

Functions of IgE

A

Activates mast cells

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10
Q

4 ways that mast cell activation can occur

A

Crosslinking of surface IgE
Via complement (C3a and C5a)
Via nerves
Direct pathogen contact

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11
Q

What happens once mast cells are activated

A

Mediators are released

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12
Q

What mediators are released by mast cells

A

Histamine
Leukotrienes
Prostaglandins

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13
Q

What is the action of histamine

A

Increases permeability of post capillary venules, arteriole vasodilation, smooth muscle constriction

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14
Q

What is the action of leukotrienes

A

Increases permeabilty of post capillary venules, chemotaxis

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15
Q

What is the action of prostaglandins

A

Arteriolar dilation

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16
Q

Define atrophy

A

Inherited predisposition to make IgE to common environemental antigens

17
Q

What are some examples of local manifestations of type 1 sensitivity

A 
eczema
allergic rhinitis
asthma
uticeria
angioderma
18
Q

What are some examples of systemic type 1 sensitivity

A

Anaphylactic shock

19
Q

What is blood pressure like in anaphylactic shock and why

A

Low due to fluid leaking to interstitial dilation in great veins

20
Q

Is there bronchoconstriction or bronchodilation in anaphylactic shock

A

Bronchoconstriction

21
Q

Name some skin symptoms of anaphylactic shock

A

Utircaria
Red itchy eyes
Erythema

22
Q

Where in the body does angioedema occur

A

Face, lips, hands, feets, pharynx and larynx

23
Q

What is first treatment for anaphylaxis

A

Adrenaline

24
Q

How much adrenaline is administered IM

A

500mg in 0.5mls

25
Q

How much adrenaline is administereed via epipen

A

300mg in 0.3mls

26
Q

When would adrenaline by administered via slow IV?

A

Impaired circulation

27
Q

Other than adrenaline, how else may anaphylaxis be treated

A

Oxygen
Antihistamines (chloropheniramine)
Glucocorticosteroids

CR 2 (33 decks)

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