Reproduction

Question 1

Oral contraceptive - COCP and POP DDI

Answer 1

CYP 450 inducers
Carbamazepine
Rifampicin
St Johns Wart

Question 2

HRT unopposed oestrogen increases risk of what cancers?

Answer 2

Endometrial and Ovarian

Question 3

HRT oestrogen and progesterone increases risk of what?

Answer 3

Breast cancer
Thromboemoblism
CVD
Stroke

Question 4

What do you use to treat osteoporosis

Answer 4

Bisphosphonates e.g. Alendronic acid

prophylaxis and treatment

Question 5

Alendronic acid MoA

Answer 5

Reduced bone turnover by controlling osteoclast activity

Question 6

Alendronic Acid ADR

Answer 6

Oesophagitis- sit upright for 30 mins

hypocalcaemia

Question 7

Mifepristone MoA

Answer 7

progesterone receptor antagonist
termination of pregnancy
sensitises myometrium to prostaglandin-induced contractions

Question 8

Tamoxifen MoA

Answer 8

Endometrial- ER agonist- hyperplasia

Breast- ER antagonist- cell cycle arrest(breast cancer)

Question 9

Clomiphene MoA

Answer 9

increases production of anterior pituitary hormones, inducing ovulation

Question 10

Ulipristal acetate MoA

Answer 10

selective progesterone receptor modulator (partial progesterone antagonist effect)
emergency contraception- delays or inhibits ovualtion