Anti-cancer

Question 1

Growth fraction

Answer 1

Proportion of cells dividing at a given time
Indicator of sensitivity to chemotherapeutic agents
Large growth fraction- more responsive

Question 2

Alkylating agents example

Answer 2

Carmustine

Question 3

Alkylating agents MoA

Answer 3

Alkyl groups of drug form covalent bonds with cell

Cross links between DNA

Question 4

Platinum compound example

Answer 4

Cisplatin

Question 5

Platinum Compounds MoA

Answer 5

Inter and Intra adducts to inhibit DNA synthesis

Question 6

Antimetabolite examples

Answer 6

Methotrexate

5- fluorouracil

Question 7

Methotrexate MoA

Answer 7

Inhibits dihydrofolate reductase

Prevents purine synthesis

Question 8

5-fluoruracil MoA

Answer 8

Inhibits thymidylate and pyrimidine synthesis

Question 9

Spindle poison examples

Answer 9

Vinca alkaloids

Taxanes

Question 10

Spindle poisons MoA

Answer 10

Inhibit polymerisation or stimulate polymerisation and inhibit depolymerisation of micro tubules
Inhibit proliferation

Question 11

Chemotherapy general side effects

Answer 11

Alopecia
Vomiting
Skin toxicity
Mucositis

Question 12

Cisplatin and Carboplatin toxicity

Answer 12

Ototoxicity

Nephrotoxicity

Question 13

Vincritstine toxicity

Answer 13

Peripheral neuropathy

Question 14

Bleomycin and Busulfan toxicity

Answer 14

Pulmonary fibrosis

Question 15

Trastuzumab and doxorubicin toxicity

Answer 15

Cardiotoxicity

Question 16

Cyclophosphamide toxicity

Answer 16

Haemorrhagic cystitis

Question 17

Methotrexate and 5FU toxicity

Answer 17

Myleosupression