NSAIDs

Question 1

PGI2 role

Answer 1

Vasodilation

inhibit platelet aggregation

Question 2

TXA2 role

Answer 2

Vasoconstriction

platelet aggregation

Question 3

PGE2 role

Answer 3

gastrointestinal mucosal production

Question 4

NSAIDs MoA

Answer 4

Inhibits COX

decrease prostaglandin, prostacyclin and thromboxane synthesis

Question 5

NSAIDs analgesia

Answer 5

decrease peripheral pain fibre sensitivity by blocking PGE2

Question 6

NSAIDs anti-inflammatory

Answer 6

decrease prostaglandin mediated increase in vasodilation and oedema

Question 7

NSAIDs anti-pyretic

Answer 7

inhibit hypothalamic COX-2 where cytokine induced prostaglandin synthesis is elevated

Question 8

NSAIDs GI considerations

Answer 8

Peptic ulcer
Dyspepsia
Decrease mucous and bicarbonate secretion
Decrease mucosal blood flow

Question 9

NSAIDs Renal considerations

Answer 9

CKD
decrease GFR
Increase reabsorption of Na and H2O as prostaglandins usually inhibit this.

Question 10

NSAIDs DDI

Answer 10

Kidney- ACEi, ARBs, diuretics
Aspirin
Anticoagulants

Question 11

COX-2 selective

Answer 11

Celecoxib & Etoricoxib
less GI ADRs
unopposed aggregator effects