Neurology

Question 1

DOPA decarboxylase inhibitor

Answer 1

Co-careldopa

Question 2

Dopamine degradation

Answer 2

Monoamine oxidase

COMT

Question 3

Levodopa disadvanatges

Answer 3

decrease efficacy as disease progresses
involuntary movements
on/off motor complications
loss of efficacy

Question 4

Levodopa DDIs

Answer 4

Vitamin B6 increases peripheral levodopa breakdown

MAOIs –> hypertensive crisis

Question 5

Dopamine receptor agonist examples

Answer 5

Ropinirole or Rotigotine (patch- dysphagia)

Question 6

Advantages dopamine receptor agonists

Answer 6

Direct acting

neuroprotection pssible

Question 7

Dopamine receptor agonists ADRs

Answer 7

sedation

hallucinations

Question 8

Monoamine oxidase B inhibitors example

Answer 8

Selegiline

Question 9

MAO B inhibitors MoA

Answer 9

enhance dopamine

MOA B usually metabolises dopamine in the brain

Question 10

COMT inhibitors example

Answer 10

Entacapone

Question 11

COMT inhibitor MoA

Answer 11

reduces peripheral breakdown of LDOPA
spares L-DOPA
not effective alone

Question 12

Acetylcholinesterase inhibitors example

Answer 12

pyridostigmine or neostigmine

Question 13

Acetylcholinesterase inhibitors MoA

Answer 13

Enhance neurotransmission by preventing breakdown of ACH

Question 14

Acetylcholinesterase inhibitor side effects

Answer 14

Salivation
Lacrimation
Urination
Defecation
GI upset
Emesis

Question 15

Acetylcholinesterase inhibitor use

Answer 15

Myasthenia Gravis