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Clinical Pharmacology > Hypertension > Flashcards

Hypertension Flashcards

1
Q

Stage 1 hypertension

A

> 140/90

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2
Q

Stage 2 hypertension

A

> 160/100

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3
Q

Stage 3 hypertension

A

> 180 SBP or > 120 DBP

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4
Q

ACE inhibitors example

A

Ramipril or lisinopril

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5
Q

ACE inhibitors MoA

A 
Inhibits ACE to limit conversion of Ang I to Ang II 
Vasodilation
Decrease aldosterone
decrease ADH
Increase Bradykinin (vasodilator)
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6
Q

ACE inhibitors ADR

A

dry cough
hypotension
Angio-oedema
hyperkalaemia

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7
Q

ACE inhibitor warnings

A

renal artery stenosis
pregnancy
Angio-oedema

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8
Q

Angiotensin II receptor blockers example

A

Candesartan and Losartan

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9
Q

Angiotensin II receptor blocker MoA

A

Blocks AT1

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10
Q

Angiotensin II receptor blocker DDI

A

NSAIDs- kidney function

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11
Q

Ca channel blockers- dihydropyridines example

A

Amplodipine, nifedipine, nimodipine

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12
Q

Ca channel blockers MoA

A

Peripheral vasculature
Nimodipine is cerebral vasculature selective
Vasodilation

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13
Q

Ca channel blocker ADR

A

ankle swelling
flushing
headaches
palpitations (compensatory tachycardia)

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14
Q

Ca channel blocker DDI

A

simvastatin and amlodipine - amlodipine increases conc of simvastatin (CYP34A inhibitor)

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15
Q

Thiazides example

A

Indapamide or Bendroflumethiazide

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16
Q

Thiazide MoA

A

Inhibits Na/Cl co-transporter in DCT

long term effects- decrease sensitivity of vascular smooth muscle to vasoconstrictors

17
Q

Thiazide ADRs

A

Hypercalcaemia (increase Ca reabsorption in DCT)
increase glucose, cholesterol and TAG
Hypokalaemia, hyponatraemia

18
Q

Drug used for resistant hypertension

A

Spironolactone

19
Q

Drug used in pregnancy for hypertension

A

Labetolol

20
Q

B blockers for hypertesnion

A

Bisoprolol, Labetolol

21
Q

B blocker for hypertension MoA

A

Decrease sympathetic tone, decrease renin secretion

decrease myocardial contraction

22
Q

B blocker for hypertension ADR

A

Bronchospasm
Heart block- AVN
Raynauds

23
Q

B blocker warnings

A

Asthma

24
Q

B blocker DDIs

A

Verapamil - asystole

25
Q

A blocker for hypertension

A

Doxasozin

26
Q

A blocker MoA

A

Blocks A1 receptor

reduces vascular peripheral resistance

Clinical Pharmacology (18 decks)

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