Repro Drugs Flashcards
What neurotransmitters regulate GnRH neuronal firing?
GABA
NE
Dopamine
Opioids/endorphins
What stimulates GnRH release?
NE
What reduces GnRH release?
Opioids (inhibit NE release) & GABA
When does dopamine have an inhibitory effect?
Non-breeding season
What increases GnRH pulse frequency?
Estrogen POSITIVE feedback
Which hormone slows down GnRH pulse frequency?
Progesterone NEGATIVE feedback –> decr. LH
GnRH receptors are coupled to _____ receptors.
Gq
List 6 steps in GnRH receptor signaling
- Activation of phospholipase C
- Generation of IP3 & DAG
- Mobilization of intracellular Ca
- Activation of PKC
- PKC activates MAP kinase
- LH & FSH synthesis & release
What leads to GnRH/gonadotropin receptor down regulation?
continuous stimulation
Gonadorelin is a synthetic ______ analogue.
GnRH
Indication for intermittent dosing of Gonadorelin.
Infertility therapy
Indications for continuous dosing of Gonadorelin. (TQ)
Chemical castration or limit estrus
List the 4 gonadotropins.
LH
FSH
hCG
eCG
% homology between LH & hCG. (TQ)
82%
Which subunit confers specificity (TQ)?
beta