Pharm Quiz 2 Flashcards
What drugs are considered NRTIs (nucleoside reverse transcriptase inhibitors)?
(3)
Zidovudine
Stampidine
Lamivudine
What viruses are affected by NRTIs?
HIV
FeLV
FIV
Which drugs are viral DNA polymerase inhibitors? (5)
Acyclovir
Idoxuridine
Ribavirin
Trifluridine
Foscarnet
What viruses are viral DNA polymerase inhibitors effective against?
Herpes
(foscarnet can also do FeLV)
What drugs are inhibitors of coat disassembly and neuramidase inhibitors? (2)
Amantadine
Rimantadine
Which viruses are effected by inhibitors of coat disassembly and neurmidase inhibitors?
influenza A or A/B
What drug is in the category of biopharmaceuticals and immunomodulators?
interferon
What viruses can interferon treat?
IBR
FeLV/FIV
CPV-2
EHV-1
What is the MOA for NRTIs?
analogues of naturally occuring deoxynucleosides
What are the veterinary applications for NRTIs?
FeLV
FIV
Bovine Leukemia Virus
What are the side effects of zidovudine (NRTIs) in cats?
hemolysis after IV injection
What drug is more potent than zidovudine when treating FIV and has better safety profile?
lamivudine
What are the veterinary applications of acyclovir?
EHV-1
FHV
CHV
Which viral DNA polymerase inhibitor is toxic to cats?
valacyclovir
Who has better bioavailability of DPIs (DNA polymerase inhibitors), foals or adult horses?
foals
Which DPI is for only for topical administration?
penciclovir
Which DPI drug is the efficacy questionable?
famciclovir
What is the M2-ion channel inhibitors MOA?
acidification of endosome, dissasembles viral structure
Which M2-ion channel inhibitor is more safe and useful in equine influenza?
rimantidine
What is amantidine useful for besides anti-viral? What receptor does it bind to?
treatment of pain
NMDA receptor antagonist (same as ketamine)
What species is amantidine well tolerated in for pain and what other pain meds can it be combined with?
well tolerated in dog
can be combined with NSAIDs
What type of drugs were used to treat the mexican swine flu?
Neuramidase/sialidase inhibitors
(zanamivir and oseltamivir)
What drug inhibits both DNA and RNA viruses?
ribavirin
What are the veterinary applications of ribavarin?
in vitro:promising
toxic in cats
not used in vivo yet in dogs and cows
What is the MOA for interferon omega?
promotes synthesis of enzymes that interfere with viral replication
cell-cell interaction cuts need for more drug
What can happen if a recombinant interferon made in one species is used to treat another?
allergies
What are used as adjuvants in viral vaccines?
agonists of innate immune receptors
What are the 3 groups of naturally occuring antifungals?
griseofulvin
polyenes (amphotericin)
echinocandins
What are the 2 groups of synthetic antifungals?
azoles
pyramidines
What is the MOA of polyenes?
binds to ergosterol in membrane - cant bind to cholesterol
ability to form pores in fungal membrane - electrolyte imbalance
What is the MOA of azoles?
blocks ergosterol synthesis (P450)
What is the MOA of flucytosine?
binds to microtubules, disrupts mitotic spindles
What is the MOA of echinocandins?
inhibit beta glucan synthesis
What is the MOA of allylamines?
inhibits squalene epoxidase to block ergosterol synthesis
What 3 drugs are polyene antibiotics?
Amphotericin B
Natamycin
Nystatin
What organisms have the least affinity for polyene antibiotics?
bacteria
Are polyene antibiotics broad or narrow spectrum?
broad
What type of infections are polyene antibiotics used for?
disseminated infections
Where is amphotericin B not readily absorbed?
GIT
poor tissue penetration in inflammation
What are the side effects of amphotericin B?
renal toxicity
hypokalemia
irritant to endothelium
liposome complex preps show less side effects
What are nystatin and natamycin used to treat?
localized superficial infections
What are the side effects of nystatin and natamycin?
vomiting and diarrhea
Are azole drugs fungistatic or fungicidal?
fungistatic
When enzyme do azole drugs inhibit and what effect does it produce?
fungal cytochrome p450 –> inhibits conversion of lanosterol to ergosterol
Which imidazole drug has the first pass effect?
clotrimazole
What are the side effects of imidazoles?
GIT upset
decrease appetite
hepatotoxicity
inhibit CYP450
inhibit PgP
Which imidazole drug is highly lipophilic and highly protein bound?
ketoconazole
What are the 4 imidazole drugs?
ketoconazole
clotrimazole
miconazole
enilconazole
What imidazole drugs have low topical absorption?
miconazole and enilconazole
Which imidazole drug reaches minimal CNS concentrations?
ketoconazole
How are most imidazoles administered?
topical
What are the 4 triazole drugs?
fluconazole
itraconazole
voriconazole
posaconazole
What ways are triazoles administered?
topical and systemic use