Repro Flashcards
Lymph drainage of ovary/testis
Para-aortic LN
Lymph drainage of distal vagina/vulva/scrotum
superficial inguinal node
Lymph drainage of proximal vagina/uterus
Obturator, external iliac and hypogastric nodes
Lymph drainage of anterior/lateral cervix
external iliac node
Lymph drainage of posterior/lateral cervix
internal iliac node
Lymph drainage of posterior cervix
obturator and presacral nodes
What do the infundibulopelvic ligaments contain?
ovarian vessels
What does the infundibulopelvic ligament do?
connects ovaries to lateral pelvic wall
What do the cardinal ligaments contain?
uterine vessels
What do the cardinal ligaments do?
connects cervix to side wall of pelvis
What does the round ligament do?
connects uterine fundus to labia majora
What does the broad ligament do?
connects uterus, fallopian tubes and ovaries to pelvic side wall
What is contained within the broad ligament?
contains ovaries, fallopian tubes and round ligaments of uterus
What does the ovarian ligament do?
connects medial pole of ovary to lateral uterus
Which female ligament is a derivative of the gubernaculum?
Round ligament
List the 3 parts of the broad ligament
mesosalpinx
mesometrium
mesovarium
Path of sperm during ejaculation.
SEVEN UP Seminiferous tubules Epididymis Vas deferens Ejaculatory ducts Nothing Urethra Penis
Erection innervation
Parasympathetic (pelvic)
Emission innervation
Sympathetic (hypogastric)
Ejaculation innervation
Visceral and somatic (pudendal)
Estrogen from ovary
17-beta-estradiol
Estrogen from placenta
estriol
Estrogen from adipose tissue
estrone
Potency of estrogens
estradiol > estrone > estriol
What female cells does FSH act on?
Granulosa cells
What female cells does LH act on?
theca cells
What triggers lactation after delivery?
fall in progesterone disinhibits prolactin
Primary oocyte cell cycle arrest
Prophase I (until ovulation)
Secondary oocyte cell cycle arrest
Metaphase II (until fertilization)
How long does it take for fertilization of an ovulated egg to occur?
must be fertilized in one day
How long does it take a fertilized egg to implant?
6 days after fertilization
When can home pregnancy tests detect beta-hCG?
2 weeks after conception
When can you detect beta-hCG in blood?
1 week after conception
Hormone levels in Klinefleters
High FSH, LH
High estrogen
Low testosterone
Hormone levels in Turners
High FSH, LH
Low estrogen
Hormone levels in defective androgen receptor
High LH
High testosterone
Hormone levels in testosterone-secreting tumors (or exogenous steroids)
High testosterone
Low LH
Hormone levels in primary hypogonadism
High LH
Low testosterone
Hormone levels in Hypogonadotropic hypogonadism
Low LH
Low testosterone
Hormone levels in aromatase deficiency
- Increase serum testosterone and androstenedione (in female infant)
- Maternal virilization (androgens cross placenta)
Hormone levels in androgen insensitivity syndrome
- High testosterone, estrogen
- High LH
Hormone levels in 5-alpha reductase deficiency
Normal testosterone/estrogen
Normal to high LH
Hormone levels in Kallmann syndrome
Low GnRH
Low FSH, LH
Low testosterone
What are the stipulations for gestational HTN?
- After 20th week
- BP >140/90
What are the stipulations for preeclampsia?
- After 20th week
- BP >140/90
- Proteinuria >300 mg/24 hours
What are the stipulations for HELLP?
- Hemolysis
- Elevated liver enzymes
- Low platelet levels
When do you deliver for gestational HTN?
39 weeks
When do you deliver for preeclampsia (mild)?
37 weeks
When do you deliver for preeclampsia (severe)?
34 weeks
When do you deliver for eclampsia or HELLP?
immediately
Treatment for endometritis
Gentamicin + clindamycin +/- ampicillin
What female cells produce progesterone and androgens?
theca interna
What stimulates theca interna?
LH
What does FSH do in the ovary?
stimulates granulosa cell to convert androgen to estradiol
Hormone levels in PCOD
High LH, High FSH (3:1 ratio)
High testosterone (low SHBG)
High estrogen
Low testosterone
What do OCPs do for PCOD?
estrogen increases SHBG and decrease LH which leads to decreased free testosterone
What does clomiphene citrate do for PCOD?
Increases fertility: BLocks negtive feedback from circulating estrogen to increase FSH and LH
What does metformin do for PCOD?
- Increase insulin sensitivity
- Decrease insulin levels
- This decreases testosterone and enables LH surge
Distention of unruptured graafian follicle
Follicular cyst
Hemorrhage into persistent CL
corpus luteum cyst
Cyst type that is often multiple and b/l
Theca-lutein cyst
Blood vessel rupture in cyst wall
Hemorrhagic cyst
Mature teratoma
dermoid cyst
Endometriosis within ovary
Endometrioid (chocolate) cyst
Common, thin-walled benign ovarian neoplasm lined with fallopian-like epithelium (often b/l)
Serous cystadenoma
Multiloculated, large benign ovarian neoplasm lined by mucus-secreting epithelium
Mucinous cystadenoma
Benign ovarian mass arising from growth of ectopic endometrial tissue
Endometrioma
Benign germ cell tumor in women 20-30 that contains tissue from all 3 germ cell layers
Mature cystic teratoma (dermoid cyst)
Benign ovarian neoplasm that looks like bladder (coffee bean nuclei on H&E; yellow colon grossly and appears encapsulated)
Brenner tumor
Benign ovarian neoplasm with bundles of spindle shaped fibroblasts
Fibroma
What is Meigs syndrome?
Triad: -Ovrian fibroma -Ascites -Hydrothorax (get pulling sensation on groin)
Benign ovarian tumors similar to granulosa cells tumors that may produce estrogen
Thecoma
Malignant ovarian neoplasm containing fetal neuroectoderm and usually thyroid tissue
immature teratoma
Most common sex cord stomal tumor with Call-Exner bodies and presents as sexual precocity in pre-adolescents (due to production of estrogen/progesterone)
Granulosa cell tumor
Most common malignant ovarian neoplasm and has psammoma bodies
serous cystadenocarcinoma
Pseudomyxoma peritonei
Mucinous cystadenocarcinoma
Malignant ovarian neoplasm with sheets of uniform “fried egg” cells and secretes hCG and LDH
Dysgerminoma
Malignant ovarin neoplasm due to malignant trophoblastic tissue
Choriocarcinoma
Schiller-Duval bodies (look like glomeruli) in ovary or testes and AFP secretion
Yolk sac (endodermal sinus) tumor (most common tumor of male infants)
Mucin-secreting signet cells
Krukenberg tumor (GI malignancy that metastasizes to ovary)
Sarcoma botryoides
Rhabdomyosarcoma variant (vaginal tumor of girls under 4 y/o that is desmin +)
Firm, fibrous “rock-hard” mass iwth sharp margins and grossly “stellate” infiltration
Invasive ductal carcinoma of breast
Orderly row of breast cancer cells “indian file” invasion
Invasive lobular carcinoma of breast
Fleshy, cellular breast mass with lymphocytic infiltrate
Medullary carcinoma of breast
Dermal lymphatic invasion by breast carcinoma
Inflammatory breast carcinoma (causes Peau d’orange)
Breast pathology with increased acini and intralobular fibrosis (associated with calcifications)
Sclerosing adenosis (not cancer but increases risk)
Treatment of acute breast mastitis (by staph aureus)
Dicloxacillin (and continue breastfeeding)
What prostate parts are enlarged in BPH?
Middle and lateral lobes (periurethral)
What prostate parts are affected by adenocarcinoma?
posterior lobe (peripheral zone)
Hormone levels in cryptorchidism
Low inhibin
High FSH, High LH
Testosterone (low if b/l, normal if u/l)
Painless homogenous testituclar enlargement in 3rd decade (high ALP)
Seminoma
Testicular tumor in boy <3 y/o (with Schiller-Duval bodies)
Yolk sac tumor
Testicular tumor with trophoblastic elements (may metastasize to lung and brain and see high hCG)
Choriocarcinoma
Teratoma in adult male prognosis
May be malignant (benign in children)
Malignant, hemorrhagic and painful testicular mass with necrosis and glandular/papillary morphology (high hCG when pure, high AFP when mixed)
Embryonal carcinoma
Reinke crystals
Leydig cell testicular tumor
Most common testicular cancer in old men
testicular lymphoma (metastases)
Leukoplakia on penile shaft
Bowen disease (squamous cell carcinoma in situ)
Erythroplakia on glans penis
Erythroplasia of Queyrat (squamous cell carcinoma in situ)
Reddish penis papules
Bowenoid papulosis (squamous cell carcinoma in situ)